Coixol
Coixol structure
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Common Name | Coixol | ||
|---|---|---|---|---|
| CAS Number | 532-91-2 | Molecular Weight | 165.146 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 292.97°C (rough estimate) | |
| Molecular Formula | C8H7NO3 | Melting Point | 151-156ºC(lit.) | |
| MSDS | N/A | Flash Point | N/A | |
Use of CoixolCoixol is a natural product extracted from Coix Lachryma-Jobi var. ma-yuen.IC50 value:Target:In vitro: Confluent NCI-H292 cells were pretreated with oleic acid, linoleic acid, glyceryl trilinoleate, beta-stigmasterol or coixol for 30 min and then stimulated with PMA (phorbol 12-myristate 13-acetate), EGF (epidermal growth factor) or TNF-α (tumor necrosis factor-α) for 24 h. Coixol inhibited the expression of MUC5AC mucin gene and production of MUC5AC mucin protein, induced by EGF or TNF-α from NCI-H292 cells; Coixol decreased PMA-induced MUC5AC mucin secretion from NCI-H292 cells [1]. βTC-6 cells were incubated in 2 mM and 20 mM glucose in thepresence of coixol (200 μM) for 60 min at 37°C in Krebs-RingerBicarbonate buffer. Decreased insulin staining was observed by coixol at 20 mM glucose (bottom) suggest that coixol stimulated insulin secretion at high glucose concentration [2].In vivo: |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 6-methoxy-2-benzoxazolinone |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Coixol is a natural product extracted from Coix Lachryma-Jobi var. ma-yuen.IC50 value:Target:In vitro: Confluent NCI-H292 cells were pretreated with oleic acid, linoleic acid, glyceryl trilinoleate, beta-stigmasterol or coixol for 30 min and then stimulated with PMA (phorbol 12-myristate 13-acetate), EGF (epidermal growth factor) or TNF-α (tumor necrosis factor-α) for 24 h. Coixol inhibited the expression of MUC5AC mucin gene and production of MUC5AC mucin protein, induced by EGF or TNF-α from NCI-H292 cells; Coixol decreased PMA-induced MUC5AC mucin secretion from NCI-H292 cells [1]. βTC-6 cells were incubated in 2 mM and 20 mM glucose in thepresence of coixol (200 μM) for 60 min at 37°C in Krebs-RingerBicarbonate buffer. Decreased insulin staining was observed by coixol at 20 mM glucose (bottom) suggest that coixol stimulated insulin secretion at high glucose concentration [2].In vivo: |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 292.97°C (rough estimate) |
| Melting Point | 151-156ºC(lit.) |
| Molecular Formula | C8H7NO3 |
| Molecular Weight | 165.146 |
| Exact Mass | 165.042587 |
| PSA | 55.23000 |
| LogP | 1.07 |
| Appearance of Characters | light tan |
| Index of Refraction | 1.563 |
| InChIKey | MKMCJLMBVKHUMS-UHFFFAOYSA-N |
| SMILES | COc1ccc2[nH]c(=O)oc2c1 |
| Storage condition | 2-8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|---|
| Safety Phrases | S22-S24/25 |
| WGK Germany | 3 |
| RTECS | DM5275200 |
| HS Code | 2934999090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 10 | |
|---|---|
| DownStream 2 | |
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CAS#:57-13-6![5-CHLORO-6-METHOXYBENZO[D]OXAZOL-2(3H)-ONE structure](https://image.chemsrc.com/caspic/112/1750-47-6.png)
CAS#:1750-47-6
CAS#:62637-32-5This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 6-Methoxybenzo[d]oxazol-2(3H)-one |
| MFCD00051726 |
| 6-methoxy-3H-1,3-benzoxazol-2-one |
| 6-Methoxy-1,3-benzoxazol-2(3H)-one |
| Coixol |
| 6-Methoxy-2(3H)-benzoxazolone |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the InChIKey of 6-methoxy-2-benzoxazolinone? |
| A: InChIKey of 6-methoxy-2-benzoxazolinone is MKMCJLMBVKHUMS-UHFFFAOYSA-N. |
| Q: What is the physical appearance of 6-methoxy-2-benzoxazolinone? |
| A: 6-methoxy-2-benzoxazolinone appears as light tan. |
| Q: What is the safety information for 6-methoxy-2-benzoxazolinone? |
| A: Safety information for 6-methoxy-2-benzoxazolinone: S22-S24/25. |
| Q: What are the storage conditions for 6-methoxy-2-benzoxazolinone? |
| A: Storage conditions for 6-methoxy-2-benzoxazolinone: 2-8°C. |
| Q: What is the molecular formula of 6-methoxy-2-benzoxazolinone? |
| A: Molecular formula of 6-methoxy-2-benzoxazolinone is C8H7NO3. |
| Q: What is the CAS number of 6-methoxy-2-benzoxazolinone? |
| A: CAS number of 6-methoxy-2-benzoxazolinone is 532-91-2. |
| Q: What is the LogP of 6-methoxy-2-benzoxazolinone? |
| A: LogP of 6-methoxy-2-benzoxazolinone is 1.07. |
| Q: What is the molecular weight of 6-methoxy-2-benzoxazolinone? |
| A: Molecular weight of 6-methoxy-2-benzoxazolinone is 165.146. |
| Q: What English synonyms does 6-methoxy-2-benzoxazolinone have? |
| A: English synonyms of 6-methoxy-2-benzoxazolinone: 6-Methoxybenzo[d]oxazol-2(3H)-one, MFCD00051726, 6-methoxy-3H-1,3-benzoxazol-2-one, 6-Methoxy-1,3-benzoxazol-2(3H)-one, Coixol, 6-Methoxy-2(3H)-benzoxazolone. |
| Q: What is the boiling point of 6-methoxy-2-benzoxazolinone? |
| A: Boiling point of 6-methoxy-2-benzoxazolinone is 292.97°C (rough estimate). |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |