DiOC7(3)

Modify Date: 2024-01-09 16:29:05

DiOC7(3) Structure
DiOC7(3) structure
Common Name DiOC7(3)
CAS Number 53213-83-5 Molecular Weight 600.57400
Density N/A Boiling Point N/A
Molecular Formula C31H41IN2O2 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger

 Use of DiOC7(3)


DiOC7(3) (3,3'-Diheptyloxacarbocyanine iodide) is a green membrane potential probe (Ex=450-490 nm, Em=510-520 nm). DiOC7(3) can be used to quantify the vascular densities[1].

 Names

Name 3,3'-diheptyloxacarbocyanine iodide
Synonym More Synonyms

 DiOC7(3) Biological Activity

Description DiOC7(3) (3,3'-Diheptyloxacarbocyanine iodide) is a green membrane potential probe (Ex=450-490 nm, Em=510-520 nm). DiOC7(3) can be used to quantify the vascular densities[1].
Related Catalog
In Vivo Identification for tumour vasculature (frozen section): Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs)[1]. 1. The dye is administered to murine via lateral tail vein injection at a dose of 1 mg/kg/ in 50 μL volume. 2. Animals are killed 5 min after dye administration, and tumors are immediately excised and frozen at - 20°C. 3. Frozen sections 10 μm in thickness are rewarmed to room temperature, allowed to air dry. 4. Image using a microscope with 100W mercury lamp illumination and an epifluorescence condenser (excited at 430-490 nm, emitted at 510-520 nm.
References

[1]. M J Trotter, et al. Use of a carbocyanine dye as a marker of functional vasculature in murine tumours. Br J Cancer. 1989 May;59(5):706-9.

 Chemical & Physical Properties

Molecular Formula C31H41IN2O2
Molecular Weight 600.57400
Exact Mass 600.22100
PSA 35.09000
LogP 4.98780

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H315-H319-H335-H360
Precautionary Statements P201-P261-P305 + P351 + P338-P308 + P313
Personal Protective Equipment Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T: Toxic;
Risk Phrases R61;R36/37/38
Safety Phrases S53
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles4

More Articles
Tissue penetration and activity of camptothecins in solid tumor xenografts.

Mol. Cancer Ther. 13(11) , 2727-37, (2014)

The ability of a panel of camptothecin derivatives to access the tumor compartment was evaluated to determine the mechanisms by which the architecture of solid tumors may act to limit their activity. ...

Use of a carbocyanine dye as a marker of functional vasculature in murine tumours.

Br. J. Cancer 59 , 706, (1989)

An intravenously administered fluorescent carbocyanine dye, DiOC7(3), has been evaluated for use in conjunction with Hoechst 33342 as a marker of murine tumour vasculature. DiOC7(3) stains cells immed...

Pontentiometric cyanine dyes are sensitive probes for mitochondria in intact plant cells : kinetin enhances mitochondrial fluorescence.

Plant Physiol. 84 , 1385, (1987)

Selected fluorescent dyes were tested for uptake by mitochrondria in intact cells of barley, maize, and onion. The cationic cyanine dye 3,3'-diheptyloxacarbocyanine iodide [DiOC(7)(3)] accumulated in ...

 Synonyms

BENZOXAZOLIUM,3-HEPTYL-2-[3-(3-HEPTYL-2(3H)-BENZOXAZOLYLIDENE)-1-PROPENYL]-,IODIDE
MFCD00274413
D 378
3-HEPTYL-2-((E)-3-[3-HEPTYL-1,3-BENZOXAZOL-2(3H)-YLIDENE]-1-PROPENYL)-1,3-BENZOXAZOL-3-IUM IODIDE
3,3''-DIHEPTYLOXACARBOCYANINE IODIDE [DIOC7(3)]
3,3-diheptyloxacarboxycyanine iodide
DiOC7(3) [3,3'-Diheptyloxacarbocyanine iodide]
DIOC7(3)
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