Atilmotin

Modify Date: 2025-08-25 14:20:40

Atilmotin Structure
Atilmotin structure
Common Name Atilmotin
CAS Number 533927-56-9 Molecular Weight 1753.11
Density N/A Boiling Point N/A
Molecular Formula C86H135N20O19+ Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Atilmotin


OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pKd of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents[1][2].

 Names

Name 8565
Synonym More Synonyms

 Atilmotin Biological Activity

Description OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pKd of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents[1][2].
Related Catalog
Target

pKd: 8.94 (Motilin Receptor)[1]

References

[1]. Peeters T L. Motilin and the Discovery and Development of Motilinomimetics. Old Herborn University Seminar Monograph. INSTITUTE FOR MICROBIOLOGY AND BIOCHEMISTRY, 1997, 9: 77-87.

[2]. Korimilli A, Parkman HP. Effect of atilmotin, a motilin receptor agonist, on esophageal, lower esophageal sphincter, and gastric pressures. Dig Dis Sci. 2010 Feb;55(2):300-6.

 Chemical & Physical Properties

Molecular Formula C86H135N20O19+
Molecular Weight 1753.11
Exact Mass 1751.013428
LogP -1.50

 Synonyms

8565
4WQQ18VL49
L-Lysinamide, N-[(2S)-1-oxo-3-phenyl-2-(trimethylammonio)propyl]-L-valyl-L-prolyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-tyrosylglycyl-L-α-glutamyl-L-leucyl-L-glutaminyl-D-arginyl-L-leucyl-, inne r salt
N-[(2S)-3-Phenyl-2-(trimethylammonio)propanoyl]-L-valyl-L-prolyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-tyrosylglycyl-5-oxidanidyl-5-oxidanylidene-L-norvalyl-L-leucyl-L-glutaminyl-D-arginyl-L-leucyl-L-lysinamide
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