3-chloro-p-anisidine

Modify Date: 2025-08-25 16:33:03

3-chloro-p-anisidine Structure
3-chloro-p-anisidine structure
Common Name 3-chloro-p-anisidine
CAS Number 5345-54-0 Molecular Weight 157.598
Density 1.2±0.1 g/cm3 Boiling Point 271.1±20.0 °C at 760 mmHg
Molecular Formula C7H8ClNO Melting Point 50-55 °C(lit.)
MSDS Chinese USA Flash Point 117.7±21.8 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 3-Chloro-4-methoxyaniline
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 271.1±20.0 °C at 760 mmHg
Melting Point 50-55 °C(lit.)
Molecular Formula C7H8ClNO
Molecular Weight 157.598
Flash Point 117.7±21.8 °C
Exact Mass 157.029449
PSA 35.25000
LogP 1.57
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.573
InChIKey XQVCBOLNTSUFGD-UHFFFAOYSA-N
SMILES COc1ccc(N)cc1Cl

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BZ6260000
CHEMICAL NAME :
p-Anisidine, 3-chloro-
CAS REGISTRY NUMBER :
5345-54-0
BEILSTEIN REFERENCE NO. :
0879162
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C7-H8-Cl-N-O
MOLECULAR WEIGHT :
157.61
WISWESSER LINE NOTATION :
ZR CG DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008 Paris, France) V.1- 1978- Volume(issue)/page/year: 2,77,1979
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008 Paris, France) V.1- 1978- Volume(issue)/page/year: 2,77,1979 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
550 mg/kg
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008 Paris, France) V.1- 1978- Volume(issue)/page/year: 2,77,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
510 mg/kg
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008 Paris, France) V.1- 1978- Volume(issue)/page/year: 2,77,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
650 mg/kg
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008 Paris, France) V.1- 1978- Volume(issue)/page/year: 2,77,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
670 mg/kg
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008 Paris, France) V.1- 1978- Volume(issue)/page/year: 2,77,1979

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22
Safety Phrases S22-S24/25
RIDADR UN 2233 6.1/PG 3
WGK Germany 3
RTECS BZ6260000
Packaging Group III
Hazard Class 6.1
HS Code 2922299090

 Synthetic Route

~97%

3-chloro-p-anisidine Structure

3-chloro-p-anisidine

CAS#:5345-54-0

Literature: Jin, Yi; Zhou, Zu-Yu; Tian, Wei; Yu, Qiang; Long, Ya-Qiu Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5864 - 5869

~89%

3-chloro-p-anisidine Structure

3-chloro-p-anisidine

CAS#:5345-54-0

Literature: Ragan, John A.; Makowski, Teresa W.; Castaldi, Michael J.; Hill, Paul D. Synthesis, 1998 , # 11 p. 1599 - 1603

~82%

3-chloro-p-anisidine Structure

3-chloro-p-anisidine

CAS#:5345-54-0

Literature: Rambabu; Bhavani; Swamy, Nalivela Kumara; Basaveswara Rao; Pal, Manojit Tetrahedron Letters, 2013 , vol. 54, # 9 p. 1169 - 1173

~%

3-chloro-p-anisidine Structure

3-chloro-p-anisidine

CAS#:5345-54-0

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 22 p. 5864 - 5869

~%

3-chloro-p-anisidine Structure

3-chloro-p-anisidine

CAS#:5345-54-0

Literature: Synthesis, , # 11 p. 1599 - 1603

~%

3-chloro-p-anisidine Structure

3-chloro-p-anisidine

CAS#:5345-54-0

Literature: Synthesis, , # 11 p. 1599 - 1603

~%

3-chloro-p-anisidine Structure

3-chloro-p-anisidine

CAS#:5345-54-0

Literature: Journal of the Chemical Society. Perkin Transactions 2, , # 11 p. 2230 - 2232

~%

3-chloro-p-anisidine Structure

3-chloro-p-anisidine

CAS#:5345-54-0

Literature: Journal of the Chemical Society, Perkin Transactions 2, , # 11 p. 2226 - 2229

 Customs

HS Code 2922299090
Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles1

More Articles
Rapid determination of aniline metabolites of chlorpropham in potatoes by micellar electrokinetic chromatography using negative-charged mixed micelles and laser-induced fluorescence detection.

Electrophoresis 26(15) , 2991-8, (2005)

A rapid, reliable method has been developed for the multi-residue analysis of aniline metabolites of chlorpropham in potato samples. The method involves the precolumn derivatization of aniline metabol...

 Synonyms

OCPA
3-chloro-p-anisidine
3-Chloro-4-methoxybenzenamine
3-chloro-4-methoxy-aniline
EINECS 226-298-4
Benzenamine,3-chloro-4-methoxy
3-Chloro-4-methoxyaniline
Orthochloroparanisidine
2-Chloro-4-aminoanisole
p-Anisidine,3-chloro
3-chloro-4-methoxyphenylamine
1-amino-3-chloro-4-methoxybenzene
MFCD00007771
3-Chloroanisidine
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