Cinanserin hydrochloride

Modify Date: 2025-08-25 11:22:56

Cinanserin hydrochloride Structure
Cinanserin hydrochloride structure
 Common Name Cinanserin hydrochloride
CAS Number 54-84-2 Molecular Weight 376.94300
Density N/A Boiling Point 519.5ºC at 760mmHg
Molecular Formula C20H25ClN2OS Melting Point N/A
MSDS N/A Flash Point 268ºC

 Use of Cinanserin hydrochloride


Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro[1][2][3].

 Names

Name cinanserin hydrochloride
Synonym More Synonyms

 Cinanserin hydrochloride Biological Activity

Description Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro[1][2][3].
Related Catalog
Target

Ki: 41 nM (5-HT2 receptor)[3]; 3C-like proteinase[1]

In Vitro Cinanserin/Cinanserin hydrochloride have binding affinity to SARS-CoV 3CLpro, HCoV-229E 3CLpro, with the KD values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CLpro and 18.2 μM/36.6 μM for human coronavirus 229E (HCoV-229E) 3CLpro[1]. The IC50 values of Cinanserin and Cinanserin hydrochloride for inhibiting the catalytic activity of SARS-CoV 3CLpro are calculated as 4.92 μM and 5.05 μM, respectively, The corresponding IC50 values for HCoV-229E 3CLpro are 4.68 μM and 5.68 μM. None of the compounds have inhibitory activity against HRV-14 3Cpro at concentrations up to 200 μM[1].
In Vivo Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels. Leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin[2]. Animal Model: Male Wistar rats (250 g) underwent thermal injury[2] Dosage: 5 mg/kg Administration: Intravenous injection; for 2 hours Result: Significantly reduced systemic burn edema to shamburn levels..
References

[1]. Chen L, et al. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol. 2005 Jun;79(11):7095-103.

[2]. Hernekamp JF, et al. Cinanserin reduces plasma extravasation after burn plasma transfer in rats. Burns. 2013 Sep;39(6):1226-33.

[3]. Leysen JE, et al. Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors. Life Sci. 1981 Mar 2;28(9):1015-22.

 Chemical & Physical Properties

Boiling Point 519.5ºC at 760mmHg
Molecular Formula C20H25ClN2OS
Molecular Weight 376.94300
Flash Point 268ºC
Exact Mass 376.13800
PSA 57.64000
LogP 5.25730
InChIKey LXGJPDKYMJJWRB-IERUDJENSA-N
SMILES CN(C)CCCSc1ccccc1NC(=O)C=Cc1ccccc1.Cl

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD7478000
CHEMICAL NAME :
Cinnamanilide, 2'-((3-(dimethylamino)propyl)thio)-, monohydrochloride
CAS REGISTRY NUMBER :
54-84-2
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H24-N2-O-S.Cl-H
MOLECULAR WEIGHT :
376.98
WISWESSER LINE NOTATION :
1N1&3SR BMV1U1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 152,132,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
480 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 152,132,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 152,132,1964
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 152,132,1964

 Synonyms

maptc
Cinnanserin
sq10,643
CINANSERIN
DPTC HYDROCHLORIDE
DPTC
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Cinanserin hydrochloride suppliers

Cinanserin hydrochloride price

Related Compounds: More...
1-(4-Fluorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-ol
1202029-71-7
(2-(Morpholinomethyl)benzo[D]oxazol-5-YL)methanamine
2098577-81-0
4-(4-Bromophenyl)-1-(3-chloro-4-fluorophenyl)-1H-pyrazol-5-amine
1202028-94-1
4-Isoxazolecarboxylic acid, 3-(4-fluorophenyl)-5-(trifluoromethyl)-, ethyl ester
1159978-87-6
4-(4-Chlorophenoxy)benzohydrazide
1159979-09-5
Ethyl 4-(4-chlorophenyl)-2-phenylthiazole-5-carboxylate
1199942-24-9
3-(3-(4-(Methylthio)phenyl)-1-phenyl-1H-pyrazol-4-yl)propanoic acid
1202030-01-0
6-(4-Bromophenyl)-7,7a-dihydroimidazo[2,1-b]thiazole
1159979-30-2
Ethyl 2-phenyl-4-p-tolylthiazole-5-carboxylate
1199942-20-5
n-(Cyanomethyl)-n-methyl-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide
2220163-93-7
Chemsrc provides Cinanserin hydrochloride(CAS#:54-84-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Cinanserin hydrochloride are included as well.>> amp version: Cinanserin hydrochloride

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2026 ChemSrc All Rights Reserved