Methyl protodioscin

Modify Date: 2025-08-25 18:12:08

Methyl protodioscin Structure
Methyl protodioscin structure
 Common Name Methyl protodioscin
CAS Number 54522-52-0 Molecular Weight 1063.226
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C52H86O22 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Methyl protodioscin


Methyl protodioscin(NSC-698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest.IC50 value:Target: in vitro: MPD showed growth inhibitory effects in A549 cells in a dose- and time-dependent manner. The significant G2/M cell cycle arrest and apoptotic effect were also seen in A549 cells treated with MPD. MPD-induced apoptosis was accompanied by a significant reduction of mitochondrial membrane potential, release of mitochondrial cytochrome c to cytosol, activation of caspase-3, downregulation of Bcl-2, p-Bad, and upregulation of Bax [1]. In THP-1 macrophages, MPD increases levels of ABCA1 mRNA and protein in dose- and time-dependent manners, and apoA-1-mediated cholesterol efflux. MPD also decreases the gene expressions of HMGCR, FAS and ACC for cholesterol and fatty acid synthesis [2].

 Names

Name Methylprotodioscin
Synonym More Synonyms

 Methyl protodioscin Biological Activity

Description Methyl protodioscin(NSC-698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest.IC50 value:Target: in vitro: MPD showed growth inhibitory effects in A549 cells in a dose- and time-dependent manner. The significant G2/M cell cycle arrest and apoptotic effect were also seen in A549 cells treated with MPD. MPD-induced apoptosis was accompanied by a significant reduction of mitochondrial membrane potential, release of mitochondrial cytochrome c to cytosol, activation of caspase-3, downregulation of Bcl-2, p-Bad, and upregulation of Bax [1]. In THP-1 macrophages, MPD increases levels of ABCA1 mRNA and protein in dose- and time-dependent manners, and apoA-1-mediated cholesterol efflux. MPD also decreases the gene expressions of HMGCR, FAS and ACC for cholesterol and fatty acid synthesis [2].
Related Catalog
References

[1]. Bai Y, et al. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells. Pharmacogn Mag. 2014 Jul;10(39):318-24.

[2]. Ma W, et al. Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels. Atherosclerosis. 2015 Apr;239

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C52H86O22
Molecular Weight 1063.226
Exact Mass 1062.561035
PSA 335.06000
LogP 4.17
Index of Refraction 1.620
InChIKey HSSJYSJXBOCKQM-LXNCCRCLSA-N
SMILES COC1(CCC(C)COC2OC(CO)C(O)C(O)C2O)OC2CC3C4CC=C5CC(OC6OC(CO)C(OC7OC(C)C(O)C(O)C7O)C(O)C6OC6OC(C)C(O)C(O)C6O)CCC5(C)C4CCC3(C)C2C1C
Storage condition -20°C

 Methyl protodioscinBioassay

View more

Name: Inhibition of neointima formation of injured vessel in rat model of balloon injury in...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4717320
Name: Inhibition of neointima formation of injured vessel in rat model of balloon injury in...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4717314
Name: Inhibition of neointima formation of injured vessel in rat model of balloon injury in...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4717315
Name: Inhibition of ADAM15-mediated ERK phosphorylation in rat A7r5 cells at 3 to 9 uM afte...
Source: ChEMBL
Target: Disintegrin and metalloproteinase domain-containing protein 15
External Id: CHEMBL4717312
Name: Inhibition of neointima formation of injured vessel in rat model of balloon injury in...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4717313
Name: Inhibition of neointima formation of injured vessel in rat model of balloon injury in...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4717318
Name: Inhibition of neointima formation of injured vessel in rat model of balloon injury in...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4717319
Name: Inhibition of neointima formation of injured vessel in rat model of balloon injury in...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4717316
Name: Inhibition of neointima formation of injured vessel in rat model of balloon injury in...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4717317
Name: Down regulation of MMP-2 expression in rat A7r5 cells at 3 to 9 uM after 24 hrs by We...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4717306
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 Synonyms

(3β,22R,25R)-26-(β-D-Glucopyranosyloxy)-22-methoxyfurost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranoside
methyl protoneodioscin
Methyl Protodioscin
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