Clovoxamine fumarate

Modify Date: 2025-08-25 17:58:57

Clovoxamine fumarate structure	Common Name	Clovoxamine fumarate
	CAS Number	54739-19-4	Molecular Weight	284.78200
	Density	1.12g/cm3	Boiling Point	387.8ºC at 760 mmHg
	Molecular Formula	C₁₄H₂₁ClN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	188.3ºC

Use of Clovoxamine fumarate

Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant[1][2][3].

Name	clovoxamine
Synonym	More Synonyms

Description	Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant[1][2][3].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Staroń J, et al. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine. Eur J Med Chem. 2021 Aug 5;220:113533. [2]. Saletu B, et al. Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man. J Neural Transm. 1980;49(1-2):63-86. [3]. de Jong GJ. The use of a pre-column for the direct high-performance liquid chromatographic determination of the anti-depressants clovoxamine and fluvoxamine in plasma. J Chromatogr. 1980 Aug 8;183(2):203-11.

Description

Related Catalog

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

References

[1]. Staroń J, et al. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine. Eur J Med Chem. 2021 Aug 5;220:113533.

[2]. Saletu B, et al. Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man. J Neural Transm. 1980;49(1-2):63-86.

[3]. de Jong GJ. The use of a pre-column for the direct high-performance liquid chromatographic determination of the anti-depressants clovoxamine and fluvoxamine in plasma. J Chromatogr. 1980 Aug 8;183(2):203-11.

Density	1.12g/cm3
Boiling Point	387.8ºC at 760 mmHg
Molecular Formula	C₁₄H₂₁ClN₂O₂
Molecular Weight	284.78200
Flash Point	188.3ºC
Exact Mass	284.12900
PSA	56.84000
LogP	3.53640
Index of Refraction	1.519
InChIKey	XXPVSQRPGBUFKM-SAPNQHFASA-N
SMILES	COCCCCC(=NOCCN)c1ccc(Cl)cc1

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SA8148000

CHEMICAL NAME :: 1-Pentanone, 1-(4-chlorophenyl)-5-methoxy-, O-(2-aminoethyl)oxime, (E)-

CAS REGISTRY NUMBER :: 54739-19-4

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H21-Cl-N2-O2

MOLECULAR WEIGHT :: 284.82

WISWESSER LINE NOTATION :: Z2ONUYR DG&4O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,563,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 681 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,563,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1215 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,563,1979

2-[(E)-[1-(4-chlorophenyl)-5-methoxypentylidene]amino]oxyethanamine

Clovoxamine

Clovoxaminum [INN-Latin]

p-Chloro-5-methoxyvalerophenone (E)-O-(2-aminoethyl)oxime

(E)-1-(4-Chlorophenyl)-5-methoxy-1-pentanone O-(2-aminoethyl)oxime

Clovoxamina [Spanish]

4'-Chloro-5-methoxyvalerophenone (E)-O-(2-aminoethyl)oxime

clovoxaminum

1-Pentanone,1-(4-chlorophenyl)-5-methoxy-,O-(2-aminoethyl)oxime,(E)

Clovoxamina [INN-Spanish]

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China
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Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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