a d lh-rh

Modify Date: 2024-04-05 14:50:36

a d lh-rh structure	Common Name	a d lh-rh
	CAS Number	54784-44-0	Molecular Weight	1206.35000
	Density	1.46g/cm3	Boiling Point	N/A
	Molecular Formula	C₅₉H₇₉N₁₅O₁₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of a d lh-rh

[D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities[1].

Name	a d lh-rh
Synonym	More Synonyms

Description	[D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Others
In Vivo	[D-Phe2,D-Ala6]-LH-RH inhibits the LH and FSH release induced by LH-RH in immature male rats[1]. [D-Phe2,D-Ala6]-LH-RH (1 mg/rat, SC) shows marked antiovulatory and contraceptive activity[2].[D-Phe2,D-Ala6]-LH-RH (0.625, 1.25, 2.5 mg/kg; s.c.; single dose; sacrificed 30 minutes) results a dose-dependent increase in stalk-median eminence (SME)-LHRH activity and decreases plasma LHRH activity as well in rats with hypophysectomized (hypox) at 25 days old[3]. [D-Phe2,D-Ala6]-LH-RH (25 mg/kg; s.c.; single dsoe) is effective in blocking the ovulation normally induced by LRH alone[4]. Animal Model: Adult female Sprague-Dawley rats (200-250 g)[2] Dosage: 1 mg/rat Administration: SC injections, from 12:00 to 14:30 hr on the day of proestrus Result: Showed marked antiovulatory and contraceptive activity, with 96% inhibition of ovulation.
References	[1]. Vilchez-Martinez JA, et al. Comparison of the anti-LH/FSH-RH and anti-ovulatory activities of (D-Phe2, D-Leu6)-LH-RH and (D-Phe2, D-Ala6)-LH-RH. Endocr Res Commun. 1976;3(3-4):231-41. [2]. Beattie CW, et al. Luteinizing hormone-releasing hormone. Antiovulatory activity of analogs substituted in positions 2 and 6. J Med Chem. 1975 Dec;18(12):1247-50. [3]. Corbin A, et al. Effect of luteinizing hormone releasing hormone (LHRH) and an LHRH antagonist of hypothalamic and plasma LHRH of hypophysectomized rats. Endocrinology. 1976 Jan;98(1):247-50. [4]. Corbin A, et al. Ihibition of the pre-ovulatory proestrous gonadotropin surge, ovulation and pregnancy with a peptide analogue of luteinizing hormone releasing hormone. Endocr Res Commun. 1975;2(1):1-23.

Density	1.46g/cm3
Molecular Formula	C₅₉H₇₉N₁₅O₁₃
Molecular Weight	1206.35000
Exact Mass	1205.60000
PSA	443.45000
LogP	2.77280
Index of Refraction	1.687

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OK6600000

CHEMICAL NAME :: Luteinizing hormone-releasing hormone, (D-phe(sup 2))-(D-ala(sup 6))-

CAS REGISTRY NUMBER :: 54784-44-0

LAST UPDATED :: 198910

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C59-H79-N15-O13

MOLECULAR WEIGHT :: 1206.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 3750 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,1247,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2500 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969- Volume(issue)/page/year: 16,359,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 30 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: EDRCAM Endocrine Research Communcations. (New York, NY) V.1-9, 1974-83. Volume(issue)/page/year: 2,1,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 12500 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: EDRCAM Endocrine Research Communcations. (New York, NY) V.1-9, 1974-83. Volume(issue)/page/year: 2,1,1975

Risk Phrases	60
Safety Phrases	53-22-36/37/39-45

GLP-DPHE-TRP-SER-TYR-DALA-LEU-ARG-PRO-GLY-NH2

[D-PHE2,D-ALA6]-LH-RH (HUMAN)

PYR-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2

[D-PHE2,D-ALA6]-LH-RH

PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2

D-phe2,D-ala6-luteinizing hormone*releasing hormo

wy-18,185

LHRH,Phe(2)-Ala(6)

(d-phe(sup2))-(d-ala(sup6))-lhrh

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.