Irigenin

Modify Date: 2024-01-02 13:05:44

Irigenin Structure
Irigenin structure
Common Name Irigenin
CAS Number 548-76-5 Molecular Weight 360.31500
Density 1.461g/cm3 Boiling Point 646.1ºC at 760mmHg
Molecular Formula C18H16O8 Melting Point 189-192ºC
MSDS N/A Flash Point 237.7ºC

 Use of Irigenin


Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells[1].

 Names

Name irigenin
Synonym More Synonyms

 Irigenin Biological Activity

Description Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells[1].
Related Catalog
In Vitro Irigenin specifically targets α9β1 and α4β1 integrin binding sites on Extra Domain A (EDA) comprising LEU46, PHE47, PRO48, GLU58, LEU59 and GLN60 in its C-C loop. Irigenin binds to the C-C loop of EDA, thereby blocking its interaction with integrins on the cell surface and thus abrogating subsequent Epithelial-Mesenchymal transition[1].
References

[1]. Amin A, et al. Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in Lung cancer cells. Sci Rep. 2016 Nov 16;6:37151.

[2]. Xu Y, et al. Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. Biochem Biophys Res Commun. 2018 Feb 12;496(3):998-1005.

 Chemical & Physical Properties

Density 1.461g/cm3
Boiling Point 646.1ºC at 760mmHg
Melting Point 189-192ºC
Molecular Formula C18H16O8
Molecular Weight 360.31500
Flash Point 237.7ºC
Exact Mass 360.08500
PSA 118.59000
LogP 2.60260
Index of Refraction 1.649
Storage condition 2-8C

 Safety Information

HS Code 2914509090

 Precursor & DownStream

Precursor  0

DownStream  2

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxychromen-4-one
7,5,3'-Trihydroxy-6,4',5'-trimethoxyisoflavon
5,7,3'-trihydroxy-6,4',5'-trimethoxyisoflavone
Irigenin
EINECS 208-958-3
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