Irigenin structure
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Common Name | Irigenin | ||
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CAS Number | 548-76-5 | Molecular Weight | 360.31500 | |
Density | 1.461g/cm3 | Boiling Point | 646.1ºC at 760mmHg | |
Molecular Formula | C18H16O8 | Melting Point | 189-192ºC | |
MSDS | N/A | Flash Point | 237.7ºC |
Use of IrigeninIrigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells[1]. |
Name | irigenin |
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Synonym | More Synonyms |
Description | Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells[1]. |
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Related Catalog | |
In Vitro | Irigenin specifically targets α9β1 and α4β1 integrin binding sites on Extra Domain A (EDA) comprising LEU46, PHE47, PRO48, GLU58, LEU59 and GLN60 in its C-C loop. Irigenin binds to the C-C loop of EDA, thereby blocking its interaction with integrins on the cell surface and thus abrogating subsequent Epithelial-Mesenchymal transition[1]. |
References |
Density | 1.461g/cm3 |
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Boiling Point | 646.1ºC at 760mmHg |
Melting Point | 189-192ºC |
Molecular Formula | C18H16O8 |
Molecular Weight | 360.31500 |
Flash Point | 237.7ºC |
Exact Mass | 360.08500 |
PSA | 118.59000 |
LogP | 2.60260 |
Index of Refraction | 1.649 |
Storage condition | 2-8C |
HS Code | 2914509090 |
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Precursor 0 | |
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DownStream 2 | |
HS Code | 2914509090 |
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Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxychromen-4-one |
7,5,3'-Trihydroxy-6,4',5'-trimethoxyisoflavon |
5,7,3'-trihydroxy-6,4',5'-trimethoxyisoflavone |
Irigenin |
EINECS 208-958-3 |