野鸢尾黄素

• 常用名: 野鸢尾黄素
• 英文名: Irigenin
• CAS号: 548-76-5
• 分子量: 360.31500
• 密度: 1.461g/cm3
• 沸点: 646.1ºC at 760mmHg
• 分子式: C₁₈H₁₆O₈
• 熔点: 189-192ºC
• 闪点: 237.7ºC

野鸢尾黄素用途

Irigenin 是一种先导化合物,通过特异性和选择性地阻断 Extra Domain A (EDA) 域的 C-C 环上 α9β1 和 α4β1 整合素结合位点,介导其抗转移作用。Irigenin 具有抗癌作用。它通过增强胃癌细胞中促凋亡分子的表达来敏化 TRAIL 诱导的凋亡。

野鸢尾黄素名称

• 中文名: 野鸢尾黄素
• 英文名: irigenin
• 中文别名: 野鸢尾苷元

野鸢尾黄素生物活性

• 描述: Irigenin 是一种先导化合物,通过特异性和选择性地阻断 Extra Domain A (EDA) 域的 C-C 环上 α9β1 和 α4β1 整合素结合位点,介导其抗转移作用。Irigenin 具有抗癌作用。它通过增强胃癌细胞中促凋亡分子的表达来敏化 TRAIL 诱导的凋亡。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞骨架 >> Integrin
• 体外研究: Irigenin特异性靶向C-C环中包含LEU46、PHE47、PRO48、GLU58、LEU59和GLN60的额外结构域A(EDA)上的α9β1和α4β1整合素结合位点。Irigenin与EDA的C-C环结合,从而阻断其与细胞表面整合素的相互作用,从而阻断随后的上皮-间质转化[1]。
• 参考文献:

  [1]. Amin A, et al. Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in Lung cancer cells. Sci Rep. 2016 Nov 16;6:37151.

  [2]. Xu Y, et al. Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. Biochem Biophys Res Commun. 2018 Feb 12;496(3):998-1005.

野鸢尾黄素物理化学性质

• 密度: 1.461g/cm3
• 沸点: 646.1ºC at 760mmHg
• 熔点: 189-192ºC
• 分子式: C₁₈H₁₆O₈
• 分子量: 360.31500
• 闪点: 237.7ºC
• 精确质量: 360.08500
• PSA: 118.59000
• LogP: 2.60260
• InChIKey: TUGWPJJTQNLKCL-UHFFFAOYSA-N
• SMILES: COc1cc(-c2coc3cc(O)c(OC)c(O)c3c2=O)cc(O)c1OC
• 折射率: 1.649
• 储存条件: 2-8C

野鸢尾黄素安全信息

• 海关编码: 2914509090

野鸢尾黄素海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

野鸢尾黄素靶点实验

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实验名称：Inhibition of cow milk xanthine oxidase at 50 ug/mL 来源：ChEMBL 靶标：Xanthine dehydrogenase/oxidase External Id：CHEMBL1015630

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre... 来源：11924 靶标：N/A External Id：CGM data for Cell Systems paper Dec 2015

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野鸢尾黄素英文别名

• 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxychromen-4-one
• 7,5,3'-Trihydroxy-6,4',5'-trimethoxyisoflavon
• 5,7,3'-trihydroxy-6,4',5'-trimethoxyisoflavone
• Irigenin
• EINECS 208-958-3