10β,17β-dihydroxyestra-1,4-dien-3-one
Modify Date: 2024-02-28 18:12:32
10β,17β-dihydroxyestra-1,4-dien-3-one structure
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Common Name | 10β,17β-dihydroxyestra-1,4-dien-3-one | ||
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| CAS Number | 549-02-0 | Molecular Weight | 288.381 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 485.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H24O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 261.4±25.2 °C | |
Use of 10β,17β-dihydroxyestra-1,4-dien-3-one10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1]. |
| Name | 10β,17β-dihydroxyestra-1,4-dien-3-one |
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| Synonym | More Synonyms |
| Description | 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1]. |
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| In Vivo | 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 485.3±45.0 °C at 760 mmHg |
| Molecular Formula | C18H24O3 |
| Molecular Weight | 288.381 |
| Flash Point | 261.4±25.2 °C |
| Exact Mass | 288.172546 |
| LogP | 1.82 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.607 |
| DHED |