10β,17β-dihydroxyestra-1,4-dien-3-one

Modify Date: 2024-02-28 18:12:32

10β,17β-dihydroxyestra-1,4-dien-3-one Structure
10β,17β-dihydroxyestra-1,4-dien-3-one structure
 Common Name 10β,17β-dihydroxyestra-1,4-dien-3-one
CAS Number 549-02-0 Molecular Weight 288.381
Density 1.2±0.1 g/cm3 Boiling Point 485.3±45.0 °C at 760 mmHg
Molecular Formula C18H24O3 Melting Point N/A
MSDS N/A Flash Point 261.4±25.2 °C

 Use of 10β,17β-dihydroxyestra-1,4-dien-3-one


10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1].

 Names

Name 10β,17β-dihydroxyestra-1,4-dien-3-one
Synonym More Synonyms

 10β,17β-dihydroxyestra-1,4-dien-3-one Biological Activity

Description 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1].
In Vivo 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes[1].
References

[1]. Merchenthaler I, et al. Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery. Sci Rep. 2016 Aug 1;6:30721.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 485.3±45.0 °C at 760 mmHg
Molecular Formula C18H24O3
Molecular Weight 288.381
Flash Point 261.4±25.2 °C
Exact Mass 288.172546
LogP 1.82
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.607

 Synonyms

DHED
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Chemsrc provides 10β,17β-dihydroxyestra-1,4-dien-3-one(CAS#:549-02-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 10β,17β-dihydroxyestra-1,4-dien-3-one are included as well.>> amp version: 10β,17β-dihydroxyestra-1,4-dien-3-one

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