549-02-0
549-02-0 structure
- Name: 10β,17β-dihydroxyestra-1,4-dien-3-one
- Chemical Name: 10β,17β-dihydroxyestra-1,4-dien-3-one
- CAS Number: 549-02-0
- Molecular Formula: C18H24O3
- Molecular Weight: 288.381
- Create Date: 2018-07-19 23:30:37
- Modify Date: 2024-02-28 18:12:32
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10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1].
| Name | 10β,17β-dihydroxyestra-1,4-dien-3-one |
|---|---|
| Synonyms | DHED |
| Description | 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1]. |
|---|---|
| In Vivo | 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 485.3±45.0 °C at 760 mmHg |
| Molecular Formula | C18H24O3 |
| Molecular Weight | 288.381 |
| Flash Point | 261.4±25.2 °C |
| Exact Mass | 288.172546 |
| LogP | 1.82 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.607 |