549-02-0

549-02-0 structure

Name: 10β,17β-dihydroxyestra-1,4-dien-3-one
Chemical Name: 10β,17β-dihydroxyestra-1,4-dien-3-one
CAS Number: 549-02-0
Molecular Formula: C₁₈H₂₄O₃
Molecular Weight: 288.381
Create Date: 2018-07-19 23:30:37
Modify Date: 2024-02-28 18:12:32
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1].

Name	10β,17β-dihydroxyestra-1,4-dien-3-one
Synonyms	DHED

Description	10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1].
In Vivo	10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes[1].
References	[1]. Merchenthaler I, et al. Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery. Sci Rep. 2016 Aug 1;6:30721.