Neutral Red

Modify Date: 2024-01-02 09:45:35

Neutral Red structure	Common Name	Neutral Red
	CAS Number	553-24-2	Molecular Weight	288.775
	Density	N/A	Boiling Point	497.3ºC at 760mmHg
	Molecular Formula	C₁₅H₁₇ClN₄	Melting Point	290 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	N/A

Use of Neutral Red

Neutral Red, a nitrogenous pH-indicator with a pKi of 6.8, is an indicator for the internal acidification of thylakoids. Neutral Red stains lysosomes red[1].

Name	neutral red
Synonym	More Synonyms

Description	Neutral Red, a nitrogenous pH-indicator with a pKi of 6.8, is an indicator for the internal acidification of thylakoids. Neutral Red stains lysosomes red[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	As cells begin to die, their ability to incorporate neutral red diminishes. The neutral red is also used to stain cell cultures for plate titration of viruses[2].
References	[1]. Winfried AUSLANDER, et al. NEUTRAL RED, A RAPID INDICATOR FOR pH-CHANGES IN THE INNER PHASE OF THYLAKOIDS. FEBS LETTERS. 1975 Nov. [2]. Ellen Borenfreund, et al. A simple quantitative procedure using monolayer cultures for cytotoxicity assays (HTD/NR-90). Journal of tissue culture methods volume 9, pages7–9 (1985).

Boiling Point	497.3ºC at 760mmHg
Melting Point	290 °C (dec.)(lit.)
Molecular Formula	C₁₅H₁₇ClN₄
Molecular Weight	288.775
Exact Mass	288.114166
PSA	55.04000
LogP	4.12280
Water Solubility	50 g/L

Neutral Red MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SG1400000

CHEMICAL NAME :: Phenazine, 3-amino-7-(dimethylamino)-2-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 553-24-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 22

MOLECULAR FORMULA :: C15-H16-N4.Cl-H

MOLECULAR WEIGHT :: 288.81

WISWESSER LINE NOTATION :: T C666 BN INJ E1 FZ LN1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 432 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 142 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 96600 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Bird - chicken

DOSE/DURATION :: 85 ug/kg

REFERENCE :: 47JMAE "Cytogenetic Assays of Environmental Mutagens," Hsu, T.C., ed., Totowa, NJ, Allanheld, Osmun & Co., 1982 Volume(issue)/page/year: -,137,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1598 No. of Facilities: 420 (estimated) No. of Industries: 5 No. of Occupations: 5 No. of Employees: 694 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1598 No. of Facilities: 746 (estimated) No. of Industries: 13 No. of Occupations: 12 No. of Employees: 23740 (estimated) No. of Female Employees: 19202 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R68
Safety Phrases	S36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SG1400000
HS Code	32041300

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Particle pollution in Rio de Janeiro, Brazil: increase and decrease of pro-inflammatory cytokines IL-6 and IL-8 in human lung cells.

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Pharmazie 70 , 553-8, (2015)

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N2,N2,7-Trimethylphenazine-2,8-diamine hydrochloride

3-amino-7-dimethylamino-2-methyl-phenazinium chloride

Nuclear Fast Red

NEUTRAL RED

Neutral Red W

Toluylene Red

Neutral Red chloride

3-Amino-7-dimethylamino-2-methylphenazine hydrochloride

2,8-Phenazinediamine, N8,N8,3-trimethyl-, monohydrochloride

Michrome No. 226

Neutral Red (Tautomer)

Basic Red 5

EINECS 209-035-8

8-N,8-N,3-trimethylphenazine-2,8-diamine,hydrochloride

Neutral Red Base

N8,N8,3-trimethyl-2,8-phenazinediamine monohydrochloride

C.I. Basic Red 5

N,N,3-Trimethylphenazine-2,8-diamine hydrochloride (1:1)

2,8-Phenazinediamine, N,N,3-trimethyl-, hydrochloride (1:1)

N,N,3-Trimethyl-2,8-phenazinediamine hydrochloride (1:1)

N8,N8,3-trimethylphenazine-2,8-diamine hydrochloride

MFCD04119237

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China
Product Name: Neutral Red
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China
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China
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China
Product Name: TIANFUCHEM--High purity Basic Red 5 factory price
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Price: ￥550/10 mM * 1 mL in DMSO

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Neutral Red

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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