Zinc stearate

Modify Date: 2024-01-02 16:12:52

Zinc stearate Structure
Zinc stearate structure
Common Name Zinc stearate
CAS Number 557-05-1 Molecular Weight 632.32
Density 1.095 Boiling Point 359.4ºC at 760 mmHg
Molecular Formula C36H70O4Zn Melting Point 128-130 °C (lit.)
MSDS Chinese USA Flash Point 180℃

 Use of Zinc stearate


Zinc stearate is a Zinc distearate. Zinc stearate can be used as an excipient, such as lubricants for tablets and capsules. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

 Names

Name Zinc stearate W. S
Synonym More Synonyms

 Zinc stearate Biological Activity

Description Zinc stearate is a Zinc distearate. Zinc stearate can be used as an excipient, such as lubricants for tablets and capsules. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. Lower E S. Zinc stearate: its properties and uses[J]. Pigment & Resin Technology, 1982, 11(6): 9-14.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

 Chemical & Physical Properties

Density 1.095
Boiling Point 359.4ºC at 760 mmHg
Melting Point 128-130 °C (lit.)
Molecular Formula C36H70O4Zn
Molecular Weight 632.32
Flash Point 180℃
Exact Mass 630.456543
PSA 37.30000
LogP 6.33000
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility Insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZH5200000
CHEMICAL NAME :
Zinc stearate
CAS REGISTRY NUMBER :
557-05-1
LAST UPDATED :
199712
DATA ITEMS CITED :
28
MOLECULAR FORMULA :
C36-H70-O4.Zn

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 36(4),17,1992
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intratracheal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - other changes Blood - hemorrhage
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 15,130,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 36(4),17,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
354 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 36(4),17,1992
TYPE OF TEST :
LC - Lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
>1241 mg/m3/4H
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 36(4),17,1992 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND:TWA 10 mg/m3 JAN 1993 OEL-FRANCE:TWA 10 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 6 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3;STEL 20 mg/m3 (total dust) JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ZINC STEARATE, respirable fraction-air:10H TWA 5 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ZINC STEARATE, total dust-air:10H TWA 10 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 77215 No. of Facilities: 10040 (estimated) No. of Industries: 116 No. of Occupations: 90 No. of Employees: 125011 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 77215 No. of Facilities: 21716 (estimated) No. of Industries: 163 No. of Occupations: 110 No. of Employees: 382620 (estimated) No. of Female Employees: 136358 (estimated)

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R37
Safety Phrases S22-S26-S36/37/39-S38
RIDADR NONH for all modes of transport
WGK Germany -
RTECS ZH5200000

 Synthetic Route

~97%

Zinc stearate Structure

Zinc stearate

CAS#:557-05-1

Literature: Crompton Corporation Patent: US6689894 B1, 2004 ; Location in patent: Page column 6 ;

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Zinc stearate Structure

Zinc stearate

CAS#:557-05-1

Literature: Journal of Molecular Catalysis A: Chemical, , vol. 270, # 1-2 p. 289 - 294

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Zinc stearate Structure

Zinc stearate

CAS#:557-05-1

Literature: Journal of Physical Chemistry B, , vol. 111, # 19 p. 5212 - 5217

~64%

Zinc stearate Structure

Zinc stearate

CAS#:557-05-1

Literature: Di Serio; Tesser; Dimiccoli; Cammarota; Nastasi; Santacesaria Journal of Molecular Catalysis A: Chemical, 2005 , vol. 239, # 1-2 p. 111 - 115

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Zinc stearate Structure

Zinc stearate

CAS#:557-05-1

Literature: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 66, # 4-5 p. 1048 - 1051

~0%

Detail
Literature: Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), , p. 627 - 634

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Zinc stearate Structure

Zinc stearate

CAS#:557-05-1

Literature: Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), , p. 1939 - 1944

 Articles6

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An attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopic study of gas adsorption on colloidal stearate-capped ZnO catalyst substrate.

Appl. Spectrosc. 68(1) , 88-94, (2014)

Attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopy has been applied in situ to study gas adsorption on a colloidal stearate-capped zinc oxide (ZnO) surface. Infrared spect...

Possibility of alveolar bone promoting enhancement by using lipophilic and/or hydrophilic zinc related compounds in zinc-deficient osteoporosis rats.

Biol. Pharm. Bull. 35(9) , 1496-501, (2012)

The purpose of this research is improvement of therapeutic treatment for periodontitis by using lipophilic and/or hydrophilic zinc materials. The sample suspension injections were prepared from zinc o...

 Synonyms

MFCD00013031
Octadecanoic acid, zinc salt (2:1)
Hydense
Zinc octadecanate
Metallac
Dermarone
stearic acid,zinc
talculinz
EINECS 209-151-9
Mathe
Zinc(II) stearate
Zinc dioctadecanoate
Zinc stearate
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