Chlorhexidine diacetate

Modify Date: 2024-01-02 16:36:40

Chlorhexidine diacetate Structure
Chlorhexidine diacetate structure
Common Name Chlorhexidine diacetate
CAS Number 56-95-1 Molecular Weight 625.55
Density N/A Boiling Point 699.3ºC at 760mmHg
Molecular Formula C26H38Cl2N10O4 Melting Point 153-156ºC
MSDS Chinese USA Flash Point 376.7ºC
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning

 Use of Chlorhexidine diacetate


Chlorhexidine diacetate is a biguanide disinfectant with rapid bactericidal activity against both Gram-positive and Gram-negative organism. The antibacterial effect of chlorhexidine diacetate is related to its action on the bacterial cell membrane and to precipitation of intracellular contents[1].

 Names

Name Chlorhexidine Acetate
Synonym More Synonyms

 Chlorhexidine diacetate Biological Activity

Description Chlorhexidine diacetate is a biguanide disinfectant with rapid bactericidal activity against both Gram-positive and Gram-negative organism. The antibacterial effect of chlorhexidine diacetate is related to its action on the bacterial cell membrane and to precipitation of intracellular contents[1].
Related Catalog
References

[1]. Sanchez IR, et al. Chlorhexidine diacetate and povidone-iodine cytotoxicity to canine embryonic fibroblasts and Staphylococcus aureus. Vet Surg. 1988;17(4):182-185.

 Chemical & Physical Properties

Boiling Point 699.3ºC at 760mmHg
Melting Point 153-156ºC
Molecular Formula C26H38Cl2N10O4
Molecular Weight 625.55
Flash Point 376.7ºC
PSA 204.88000
LogP 6.37470
Water Solubility H2O: 15 mg/mL, clear | 1.9 g/100 mL (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DU1930000
CHEMICAL NAME :
Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, diacetate
CAS REGISTRY NUMBER :
56-95-1
LAST UPDATED :
199504
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C22-H30-Cl2-N10.2C2-H4-O2
MOLECULAR WEIGHT :
625.64
WISWESSER LINE NOTATION :
GR DMYUM&MYUM&M6MYUM&MYUM&MR DG &QV1 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(6),309,1985 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,192,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,192,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
325 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,192,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,192,1954 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81769 No. of Facilities: 232 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1737 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81769 No. of Facilities: 76 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1050 (estimated) No. of Female Employees: 727 (estimated)

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H410
Precautionary Statements P273-P301 + P312 + P330-P391-P501
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn:Harmful
Risk Phrases R22;R43
Safety Phrases S36/37
RIDADR UN 3077 9 / PGIII
WGK Germany 3
RTECS DU1930000

 Precursor & DownStream

Precursor  0

DownStream  1

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 Synonyms

CHLORASEPT 2000
Imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(4-chlorophenyl)-, acetate (1:2)
UNII-5908ZUF22Y
EINECS 200-302-4
Chlorhexidine acetate
N,N''''-Hexane-1,6-diylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] acetate (1:2)
N,N''''-1,6-Hexanediylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] acetate (1:2)
MFCD00012532
chlorzoin
acetic acid,(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine
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