2-HYDROXY-5-METHOXY-3-UNDECYL[1,4]BENZOQUINONE

Modify Date: 2025-08-26 17:42:36

2-HYDROXY-5-METHOXY-3-UNDECYL[1,4]BENZOQUINONE structure	Common Name	2-HYDROXY-5-METHOXY-3-UNDECYL[1,4]BENZOQUINONE
	CAS Number	56005-10-8	Molecular Weight	308.41300
	Density	1.06g/cm3	Boiling Point	439.5ºC at 760mmHg
	Molecular Formula	C₁₈H₂₈O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	149.9ºC

Use of 2-HYDROXY-5-METHOXY-3-UNDECYL[1,4]BENZOQUINONE

5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, low-density lipoprotein receptor (IDOL), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1].

Name	5-O-methyl embelin
Synonym	More Synonyms

Description	5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, low-density lipoprotein receptor (IDOL), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cardiovascular Disease
In Vitro	5-O-Methylembelin（compound 3；20 μM；24 小时）显着下调 PCSK9（IC50 值为 4.9 μM）、IDOL 和 SREBP2 mRNA 表达[1]。 RT-PCR[1] Cell Line: HepG2 cells Concentration: 20 μM Incubation Time: 24 h Result: Inhibited PCSK9, IDOL, and SREBP2 mRNA expression.
References	[1]. Pisey Pel, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega. 2022 Dec 8;7(50):47296-47305.

Density	1.06g/cm3
Boiling Point	439.5ºC at 760mmHg
Molecular Formula	C₁₈H₂₈O₄
Molecular Weight	308.41300
Flash Point	149.9ºC
Exact Mass	308.19900
PSA	63.60000
LogP	4.40150
Index of Refraction	1.505
InChIKey	KHBJLRRAMCJZLZ-UHFFFAOYSA-N
SMILES	CCCCCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O

HS Code	2914690090

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Name: Antifungal activity against Pythium ultimum at 1 mg
Source: ChEMBL
Target: Globisporangium ultimum
External Id: CHEMBL984089

Name: Toxicity in Tilapia nilotica at 1 ppm within 75 mins
Source: ChEMBL
Target: Oreochromis niloticus
External Id: CHEMBL984088

Name: Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Source: ChEMBL
Target: HeLa
External Id: CHEMBL1015930

Name: Cytotoxicity against human U937 cells after 48 hrs by MTT assay
Source: ChEMBL
Target: U-937
External Id: CHEMBL1015931

Name: Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Source: ChEMBL
Target: HL-60
External Id: CHEMBL1015928

Name: Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
Source: ChEMBL
Target: Bel-7402
External Id: CHEMBL1015929

Name: Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in li...
Source: ChEMBL
Target: Polyunsaturated fatty acid 5-lipoxygenase
External Id: CHEMBL3420629

Name: Inhibition of hexa-His-tagged PAI-1 N152H/K156T/Q321L/M356I mutant (unknown origin) e...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3267156

Name: Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated fo...
Source: ChEMBL
Target: Polyunsaturated fatty acid 5-lipoxygenase
External Id: CHEMBL3420628

Name: Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in li...
Source: ChEMBL
Target: Polyunsaturated fatty acid 5-lipoxygenase
External Id: CHEMBL3420867

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5-O-Methylembelin

2-hydroxy-5-methoxy-3-undecylcyclohexa-2,5-diene-1,4-dione