5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylamide
Modify Date: 2024-01-11 14:34:07
![5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylamide Structure](https://www.chemsrc.com/caspic/432/56290-94-9.png)
5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylamide structure
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Common Name | 5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylamide | ||
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| CAS Number | 56290-94-9 | Molecular Weight | 372.41500 | |
| Density | 1.307g/cm3 | Boiling Point | 604.1ºC at 760 mmHg | |
| Molecular Formula | C20H24N2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 319.1ºC | |
Use of 5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylamideMedroxalol (RMI81968) is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects[1]. |
| Name | 5-[2-[4-(1,3-benzodioxol-5-yl)butan-2-ylamino]-1-hydroxyethyl]-2-hydroxybenzamide |
|---|---|
| Synonym | More Synonyms |
| Description | Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects[1]. |
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| Related Catalog | |
| In Vitro | Medroxalol (0.1-10 μM; 20 min) shows α- and β-adrenergic receptor antagonism in isolated rabbit aortic strip[1]. Cell Viability Assay[1] Cell Line: Isolated rabbit aortic strip Concentration: 0.1-10 μM Incubation Time: 20 min Result: Showed pA2 values of 6.09 and 7.73 for α-adrenergic receptors and β-adrenergic receptors, respevtively. |
| In Vivo | Medroxalol (oral gavage; 12.5-50 mg/kg; once daily; 12 d) treatment shows antihypertensive activity in spontaneously hypertensive rats[1]. Animal Model: Male spontaneously hypertensive rats (SHR)[1] Dosage: 12.5, 25, or 50 mg/kg Administration: Oral gavage; 12.5, 25, or 50 mg/kg; once daily; 12 days Result: Produced a dose-related fall in blood pressure. |
| Density | 1.307g/cm3 |
|---|---|
| Boiling Point | 604.1ºC at 760 mmHg |
| Molecular Formula | C20H24N2O5 |
| Molecular Weight | 372.41500 |
| Flash Point | 319.1ºC |
| Exact Mass | 372.16900 |
| PSA | 114.04000 |
| LogP | 2.95530 |
| Index of Refraction | 1.626 |
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~84%
5-[2-[[3-(1,3-b... CAS#:56290-94-9 |
| Literature: Grisar; Claxton; Bare; Dage; Cheng; Woodward Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 327 - 336 |
![methyl 5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]-2-hydroxybenzoate structure](https://www.chemsrc.com/caspic/470/56290-93-8.png)
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| RMI 81,968 |
| MEDROXALOL |
| EINECS 260-099-3 |
| Medroxalolum |