3-METHYLGLUTACONIC ACID

Modify Date: 2024-01-08 11:35:19

3-METHYLGLUTACONIC ACID Structure
3-METHYLGLUTACONIC ACID structure
Common Name 3-METHYLGLUTACONIC ACID
CAS Number 5746-90-7 Molecular Weight 144.13
Density 1.307g/cm3 Boiling Point 399.4ºC at 760mmHg
Molecular Formula C6H8O4 Melting Point 101 - 105°C (lit.)
MSDS N/A Flash Point 209.5ºC

 Use of 3-METHYLGLUTACONIC ACID


3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research[1].

 Names

Name 3-methylglutaconic acid
Synonym More Synonyms

 3-METHYLGLUTACONIC ACID Biological Activity

Description 3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research[1].
Related Catalog
References

[1]. Guilhian Leipnitz, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82(11-12):652-62.  

[2]. N L Alsip, et al. Cardiovascular effects of 3-mercaptopropionic acid and levels of GABA in regions of the brain of guinea-pigs. Neuropharmacology. 1984 Mar;23(3):349-57.  

[3]. E Girardi, et al. 3-mercaptopropionic acid-induced seizures decrease NR2B expression in Purkinje cells: cyclopentyladenosine effect. Cell Mol Neurobiol. 2010 Oct;30(7):985-90.  

[4]. Leipnitz G, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82(11-12):652-62.  

 Chemical & Physical Properties

Density 1.307g/cm3
Boiling Point 399.4ºC at 760mmHg
Melting Point 101 - 105°C (lit.)
Molecular Formula C6H8O4
Molecular Weight 144.13
Flash Point 209.5ºC
Exact Mass 144.04200
PSA 74.60000
LogP 0.49200
Index of Refraction 1.508
Storage condition 2-8°C

 Synonyms

3-methyl-pentenedioic acid
3-METHYL-2-PENTENEDIOIC ACID
glutacouic acide 3-methyl
3-methylglutaric acid
3-Methylglutaconsaeure
3-METHYL-PENT-2-ENEDIOIC ACID
3-Methyl-pentendisaeure
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