Substance P(1-4)

Modify Date: 2024-01-02 21:05:40

Substance P(1-4) Structure
Substance P(1-4) structure
Common Name Substance P(1-4)
CAS Number 57468-16-3 Molecular Weight 496.60400
Density N/A Boiling Point N/A
Molecular Formula C22H40N8O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Substance P(1-4)


Substance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation[1].

 Names

Name 1-[6-amino-2-[[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid
Synonym More Synonyms

 Substance P(1-4) Biological Activity

Description Substance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation[1].
Related Catalog
In Vitro Substance P(1-4) (0.1 nM-1 μM) inhibits endogenous erythroid colony (EEC) formation in PV bone marrow cultures[1]. Substance P(1-4) (0.1 nM-1 μM; CD36+/GpA- cells) decreases of erythroid colony numbers of 47% and inhibits proliferation of PV CD36+/GpA- cells of 30 %[1]. Cell Viability Assay[1] Cell Line: PV CD36+/GpA- cells Concentration: 0.1 nM-1 μM Incubation Time: 2 days Result: Inhibited proliferation of PV CD36+/GpA- cells of 30 %. Apoptosis Analysis[1] Cell Line: PV CD36+/GpA- cells Concentration: 10 nM Incubation Time: 2 days Result: Increased the percentage of cell death of 27.3%.

 Chemical & Physical Properties

Molecular Formula C22H40N8O5
Molecular Weight 496.60400
Exact Mass 496.31200
PSA 220.96000
LogP 1.11560

 Synonyms

Arg-Pro-Lys-Pro
1-(6-amino-2-{[1-(2-amino-5-carbamimidamidopentanoyl)pyrrolidin-2-yl]formamido}hexanoyl)pyrrolidine-2-carboxylic acid
substance P(1-4)
SUBSTANCE P,Fragment 1-4