VAF347
Modify Date: 2024-01-11 18:31:50
VAF347 structure
|
Common Name | VAF347 | ||
|---|---|---|---|---|
| CAS Number | 574759-62-9 | Molecular Weight | 349.73800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H11ClF3N3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VAF347VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14+CD11b+ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects[1]. |
| Name | 4-(3-chlorophenyl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine |
|---|---|
| Synonym | More Synonyms |
| Description | VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14+CD11b+ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects[1]. |
|---|---|
| Related Catalog | |
| Target |
Aryl hydrocarbon receptor[1] |
| In Vitro | VAF347 (0.01-20 μM; 48-72 hours; HL-60 cells) treatment enhances retinoic acid-induced cell cycle arrest[1]. VAF347 (20 μM; 48 hours; HL-60 cells) treatment augments retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. Several interactions of partners in the signalsome appear to be enhanced: Fgr interaction with c-Cbl, CD38, and with pS259c-Raf and AhR interaction with c-Cbl and Lyn[1]. Cell Cycle Analysis[1] Cell Line: HL-60 cells Concentration: 10 nM, 100 nM, 1 μM, 10 μM, 20 μM Incubation Time: 48 hours or 72 hours Result: Enhanced retinoic acid-induced cell cycle arrest in G1/0. Western Blot Analysis[1] Cell Line: HL-60 cells Concentration: 20 μM Incubation Time: 48 hours Result: Augmented retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. |
| References |
| Molecular Formula | C17H11ClF3N3 |
|---|---|
| Molecular Weight | 349.73800 |
| Exact Mass | 349.05900 |
| PSA | 37.81000 |
| LogP | 5.63240 |
| Storage condition | 2-8°C |
| vaf347 |