γ-Acetylenic GABA

Modify Date: 2024-01-09 08:19:02

γ-Acetylenic GABA Structure
γ-Acetylenic GABA structure
Common Name γ-Acetylenic GABA
CAS Number 57659-38-8 Molecular Weight 127.14100
Density 1.155g/cm3 Boiling Point 291.1ºC at 760 mmHg
Molecular Formula C6H9NO2 Melting Point N/A
MSDS Chinese USA Flash Point 129.8ºC

 Use of γ-Acetylenic GABA


γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA can increase the concentration of GABA in rat brain[1][2][3].

 Names

Name 4-aminohex-5-ynoic acid
Synonym More Synonyms

 γ-Acetylenic GABA Biological Activity

Description γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA can increase the concentration of GABA in rat brain[1][2][3].
Related Catalog
Target

GABA-transaminase[1]

In Vivo γ-Acetylenic GABA (100 mg/kg i.p.) inhibits GABA-transaminase activity and causes a several-fold increase in the concentration of GABA in rat brain[2].
References

[1]. Casey DE, et, al. gamma-Acetylenic GABA in tardive dyskinesia. Arch Gen Psychiatry. 1980 Dec;37(12):1376-9.

[2]. Palfreyman MG, et, al. The effect of gamma-acetylenic GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase, on dopamine pathways of the extrapyramidal and limbic systems. Eur J Pharmacol. 1978 Aug 15;50(4):325-36.

[3]. Alabed S, et, al. Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2011 Apr 13;(4):CD000203.

 Chemical & Physical Properties

Density 1.155g/cm3
Boiling Point 291.1ºC at 760 mmHg
Molecular Formula C6H9NO2
Molecular Weight 127.14100
Flash Point 129.8ºC
Exact Mass 127.06300
PSA 63.32000
LogP 0.51200
Index of Refraction 1.506

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MR0180450
CHEMICAL NAME :
5-Hexynoic acid, 4-amino-
CAS REGISTRY NUMBER :
57659-38-8
LAST UPDATED :
199103
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H9-N-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
310 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
REFERENCE :
NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 21,803,1982

 Safety Information

Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36
HS Code 2922499990

 Synthetic Route

~%

γ-Acetylenic GABA Structure

γ-Acetylenic GABA

CAS#:57659-38-8

Literature: Metcalf,B.W.; Casara,P. Tetrahedron Letters, 1975 , p. 3337 - 3340

 Precursor & DownStream

Precursor  1

DownStream  1

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Synonyms

5-Hexynoic acid,4-amino
Acetylenic GABA-7
4-aminohexynoate