L-(2,6-2H2)Tyrosine

Modify Date: 2024-01-08 16:25:09

L-(2,6-2H2)Tyrosine structure	Common Name	L-(2,6-2H2)Tyrosine
	CAS Number	57746-15-3	Molecular Weight	183.201
	Density	1.3±0.1 g/cm3	Boiling Point	385.2±32.0 °C at 760 mmHg
	Molecular Formula	C₉H₉D₂NO₃	Melting Point	>300ºC (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	186.7±25.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of L-(2,6-2H2)Tyrosine

L-Tyrosine-d2-2 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

Name	(2S)-2-amino-3-(2,6-dideuterio-4-hydroxyphenyl)propanoic acid
Synonym	More Synonyms

Description	L-Tyrosine-d2-2 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
Related Catalog	Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. [3]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. [4]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. [5]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. [6]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. [7]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. [8]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. [9]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. [10]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. [11]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. [12]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35. [13]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

Density	1.3±0.1 g/cm3
Boiling Point	385.2±32.0 °C at 760 mmHg
Melting Point	>300ºC (dec.)(lit.)
Molecular Formula	C₉H₉D₂NO₃
Molecular Weight	183.201
Flash Point	186.7±25.1 °C
Exact Mass	183.086441
PSA	83.55000
LogP	0.38
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.614

L-(2,6-2H2)Tyrosine MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport

L-Tyrosine (Ring-D4)

CAS#:62595-14-6

~99%

L-(2,6-2H2)Tyrosine

CAS#:57746-15-3

Literature: Nishiyama; Oba; Ueno; Morita; Nakamura; Kainosho Journal of Labelled Compounds and Radiopharmaceuticals, 1994 , vol. 34, # 9 p. 831 - 837

Phenol D6

CAS#:13127-88-3

L-(2,6-2H2)Tyrosine

CAS#:57746-15-3

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 34, # 9 p. 831 - 837

Precursor 2
CAS#:62595-14-6 L-Tyrosine (Ring-D4) CAS#:13127-88-3 Phenol D6
DownStream 0

[2',6'-2H2]-L-tyrosine

L-(2,6-H)Tyrosine

L-Tyrosine-2,6-d2

L-4-Hydroxyphenyl-2,6-d2-alanine

L-Tyrosine-d2 (phenyl-2,6-d2)

L-Tyrosine-2,6-d

MFCD00190464

L-(2,6-2H2)Tyrosine

Use of L-(2,6-2H2)Tyrosine

Names

L-(2,6-2H2)Tyrosine Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms