Oligomycin A

Modify Date: 2024-01-02 17:27:32

Oligomycin A Structure
Oligomycin A structure
 Common Name Oligomycin A
CAS Number 579-13-5 Molecular Weight 791.063
Density 1.1±0.1 g/cm3 Boiling Point 886.3±65.0 °C at 760 mmHg
Molecular Formula C45H74O11 Melting Point 150-151ºC
MSDS Chinese USA Flash Point 252.0±27.8 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Oligomycin A


Oligomycin A, created by Streptomyces, acts as a mitochondrial F0F1-ATPase inhibitor, with a Ki of 1 μM; Oligomycin A shows anti-fungal activity.

 Names

Name Oligomycin A
Synonym More Synonyms

 Oligomycin A Biological Activity

Description Oligomycin A, created by Streptomyces, acts as a mitochondrial F0F1-ATPase inhibitor, with a Ki of 1 μM; Oligomycin A shows anti-fungal activity.
Related Catalog
Target

Ki: 1 μM (F0F1-ATPase)[1]

In Vitro Oligomycin A is a mitochondrial F0F1-ATPase inhibitor with a Ki of 1 μM. Oligomycin A shows cytotoxic to the NCI-60 cell lines, with GI50 of 10 nM. Oligomycin A also inhibits the activity of Triton X-100-solubilized ATPase with a Ki of 0.1 μM. Furthermore, Oligomycin A has anti-fungal activity[1]. Oligomycin A (2.4 µM) inhibits the ability of spermatozoa to achieve feasible in vitro capacitation (IVC), and also suppresses progesterone-induced in vitro acrosome exocytosis (IVAE) as well as the concomitant peaks of O2 consumption and ATP levels[2].
Cell Assay Drug (Oligomycin A, etc.) dilutions are added to monolayer or suspension cells in 96 well plates in triplicate for varying times. MTT is then added to the wells at a final concentration of 0.5 mg/mL. Supernatant is removed after pelleting the reduced MTT crystals. The crystals are fully dissolved in 40 mM HCl in isopropanol. Plates are scanned on a microplate reader at 595 nm[1].
References

[1]. Salomon AR, et al. Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chem Biol. 2001 Jan;8(1):71-80.

[2]. Ramió-Lluch L, et al. Oligomycin A-induced inhibition of mitochondrial ATP-synthase activity suppresses boar sperm motility and in vitro capacitation achievement without modifying overall sperm energy levels. Reprod Fertil Dev. 2014;26(6):883-97.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 886.3±65.0 °C at 760 mmHg
Melting Point 150-151ºC
Molecular Formula C45H74O11
Molecular Weight 791.063
Flash Point 252.0±27.8 °C
Exact Mass 790.523132
PSA 180.05000
LogP 6.17
Appearance of Characters white to off-white
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.543
Storage condition −20°C
Water Solubility Soluble in DMSO, ethanol or acetone

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RK3328000
CHEMICAL NAME :
Oligomycin A
CAS REGISTRY NUMBER :
579-13-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C45-H74-O11
MOLECULAR WEIGHT :
791.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 80,6092,1958

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn,T
Risk Phrases 22-68/20/21/22-20/21/22
Safety Phrases 36/37
RIDADR UN 2811
WGK Germany 3
RTECS RK3325000
Packaging Group III
Hazard Class 6.1(b)
HS Code 29419090

 Articles28

More Articles
Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.

PLoS ONE 10 , e0120295, (2015)

Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD). Based on the observations that increased expression of TRIB1 reduces se...

Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A.

Arch. Biochem. Biophys. 575 , 1-7, (2015)

Streptomyces avermitilis contains 33 cytochrome P450 genes in its genome, many of which play important roles in the biosynthesis process of antimicrobial agents. Here, we characterized the biochemical...

Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture.

PLoS ONE 10 , e0132572, (2015)

The biological consequences upon exposure of cells in culture to a dose of xenobiotic are not only dependent on biological variables, but also the physical aspects of experiments e.g. cell number and ...

 Synonyms

(1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonaMethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonaco
(1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
Oligomycin A
(1S,4E,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,27S,28R,29S)-22-Ethyl-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1S,4E,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,27S,28R,29S)-
MCH 32
MFCD00065705
OLIGOMYCIN,STREPTOMYCES DIASTATOCHROMOGENES
EINECS 209-473-3
OLIGOMYCIN A,STREPTOMYCES DIASTATOCHROMOGENES
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Oligomycin A suppliers

Price: $70/1mg

Reference only. check more Oligomycin A price

Related Compounds: More...
oligomycin a
14104-19-9
28-Oxooligomycin A
11050-94-5
12-Deoxyoligomycin A
11052-72-5
21-hydroxyoligomycin A
102042-09-1
26-Demethyloligomycin A
1404-59-7
Oligomycin A,26-hydroxy-28-oxo
110231-34-0
Oligomycin A,31-de(2-hydroxypropyl)-31-(2-hydroxybutyl)
152726-68-6
benthocyanin A
133410-66-9
de-A,B-25-cholesta-8,25-dien-8-yl trifluromethanesulfonate
113490-28-1
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
2-Amino-6-(trifluoromethyl)pyridine-3-boronic acid
2096333-25-2
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
7-methoxy-N-(2-methylbenzo[d]thiazol-5-yl)-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxamide
2034606-99-8
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
tert-Butyl-DL-alanine
1375289-11-4
Chemsrc provides Oligomycin A(CAS#:579-13-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Oligomycin A are included as well.>> amp version: Oligomycin A

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved