Bax inhibitor peptide V5

Modify Date: 2024-01-04 12:15:21

Bax inhibitor peptide V5 structure	Common Name	Bax inhibitor peptide V5
	CAS Number	579492-81-2	Molecular Weight	586.78700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₅₀N₆O₆S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Bax inhibitor peptide V5

Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment.

Name	BAX Inhibiting Peptide V5
Synonym	More Synonyms

Description	Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Peptides Research Areas >> Cancer
Target	Bax
In Vitro	Bax inhibitor peptide V5 (0-50 μM) reduces cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells. BIPV5 does not result in any significant effect on cell cycle arrest at the G2/M phase[1]. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively[2].
In Vivo	V5 (100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model[2].
Cell Assay	Cells (2.5×104 cells/mL) are grown in 96-well plates in a final volume of 100 μL/well. After 24 h, cells are incubated with small molecules or vehicle (DMSO) for 48-96 h prior to harvest. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole (MTT) reagent (0.5 mg/mL), is added to each well during the final 2 h, and absorbance is measured. Cell growth is calculated as the ratio of absorbance obtained upon compound treatment to that obtained with vehicle (DMSO) treatment.
References	[1]. Jo MJ, et al. Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment. Eur J Pharmacol. 2015 Dec 15;769:257-65. [2]. Rivas-Carrillo JD, et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes. 2007 May;56(5):1259-67. Epub 2007 Feb 7.

Molecular Formula	C₂₇H₅₀N₆O₆S
Molecular Weight	586.78700
Exact Mass	586.35100
PSA	232.72000
LogP	4.28730
Storage condition	-20°C

Bax inhibitor peptide V5 MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

L-Valyl-L-prolyl-L-methionyl-L-leucyl-L-lysine

Bax inhibitor peptide V5

DC Chemicals Limited
China
Product Name: Bax inhibitor peptide V5
Price: $400.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Bax inhibitor peptide V5
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

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Price: $108/5mg

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