1-tert-butyl-4,4-diphenylpiperidine

Modify Date: 2026-07-07 10:46:31

1-tert-butyl-4,4-diphenylpiperidine structure	Common Name	1-tert-butyl-4,4-diphenylpiperidine
	CAS Number	57982-78-2	Molecular Weight	293.446
	Density	1.0±0.1 g/cm3	Boiling Point	387.6±42.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₇N	Melting Point	108.5°C
	MSDS	N/A	Flash Point	168.7±24.8 °C

Use of 1-tert-butyl-4,4-diphenylpiperidine

Budipine is an antiparkinsonian agent.

Name	1-tert-Butyl-4,4-diphenyl-piperidine
Synonym	More Synonyms

Description	Budipine is an antiparkinsonian agent.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Reichmann H, et al. Budipine in Parkinson's tremor. J Neurol Sci. 2006 Oct 25;248(1-2):53-5.

Density	1.0±0.1 g/cm3
Boiling Point	387.6±42.0 °C at 760 mmHg
Melting Point	108.5°C
Molecular Formula	C₂₁H₂₇N
Molecular Weight	293.446
Flash Point	168.7±24.8 °C
Exact Mass	293.214355
PSA	3.24000
LogP	4.64
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.558
InChIKey	QIHLUZAFSSMXHQ-UHFFFAOYSA-N
SMILES	CC(C)(C)N1CCC(c2ccccc2)(c2ccccc2)CC1

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM7291100

CHEMICAL NAME :: Piperidine, 1-(1,1-dimethylethyl)-4,4-diphenyl-

CAS REGISTRY NUMBER :: 57982-78-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H27-N

MOLECULAR WEIGHT :: 293.49

WISWESSER LINE NOTATION :: T6NTJ AX1&1&1 DR& DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,85,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,85,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,85,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,85,1982

HS Code	2933399090

1-tert-Butylpip...

CAS#:1465-76-5

benzene

CAS#:71-43-2

1-tert-butyl-4,...

CAS#:57982-78-2

Learn More

Literature: Arzneimittel-Forschung/Drug Research, , vol. 34, # 3 p. 233 - 240

Precursor 2
CAS#:1465-76-5 1-tert-Butylpip... CAS#:71-43-2 benzene
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Binding affinity towards human ADRA2A in an in vitro assay with cellular components m...
Source: ChEMBL
Target: Alpha-2A adrenergic receptor
External Id: CHEMBL5291736

Name: Binding affinity towards human GABRA1 in an in vitro assay with cellular components m...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit gamma-2
External Id: CHEMBL5291799

Name: Binding affinity towards human PGR in an in vitro assay with cellular components meas...
Source: ChEMBL
Target: Progesterone receptor
External Id: CHEMBL5291863

Name: Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluor...
Source: ChEMBL
Target: Alpha-1A adrenergic receptor
External Id: CHEMBL5291731

Name: Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291792

Name: Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with ...
Source: ChEMBL
Target: Adenosine receptor A3
External Id: CHEMBL5291728

Name: Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay m...
Source: ChEMBL
Target: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
External Id: CHEMBL5291856

Name: Binding affinity towards human OPRM1 in an in vitro assay with cellular components me...
Source: ChEMBL
Target: Mu-type opioid receptor
External Id: CHEMBL5291855

Name: Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured...
Source: ChEMBL
Target: Alpha-1A adrenergic receptor
External Id: CHEMBL5291730

Name: Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas...
Source: ChEMBL
Target: Prothrombin
External Id: CHEMBL5291794

Total 38, Current Page 1 of 4

1-(1,1-Dimethylethyl)-4,4-diphenyl-piperidine

1-tert-butyl-4,4-diphenylpiperidine

1-(2-Methyl-2-propanyl)-4,4-diphenylpiperidine

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Purity: 98.0%
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Use of 1-tert-butyl-4,4-diphenylpiperidine

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