Febantel

Modify Date: 2024-01-03 17:16:41

Febantel Structure
Febantel structure
 Common Name Febantel
CAS Number 58306-30-2 Molecular Weight 446.477
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C20H22N4O6S Melting Point 129-130ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Febantel


Febantel is an anthelmintic for veterinary use on dogs, cats, cattle, sheep, goats, pig and poultry against roundworms and tapeworms.Target: anthelmintic compoundFebantel is a veteran anthelmintic (wormer) compound belonging to the chemical class of the benzimidazoles, but is a so-called pro-benzimidazole, i.e. it is transformed into a benzimidazole once it gets into the host's organism. Febantel it is transformed into fenbendazole in the stomach and the intestine of the host, shortly after ingestion. Once transformed its behavior is comparable to the one of fenbendazole.

 Names

Name Febantel
Synonym More Synonyms

 Febantel Biological Activity

Description Febantel is an anthelmintic for veterinary use on dogs, cats, cattle, sheep, goats, pig and poultry against roundworms and tapeworms.Target: anthelmintic compoundFebantel is a veteran anthelmintic (wormer) compound belonging to the chemical class of the benzimidazoles, but is a so-called pro-benzimidazole, i.e. it is transformed into a benzimidazole once it gets into the host's organism. Febantel it is transformed into fenbendazole in the stomach and the intestine of the host, shortly after ingestion. Once transformed its behavior is comparable to the one of fenbendazole.
Related Catalog

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Melting Point 129-130ºC
Molecular Formula C20H22N4O6S
Molecular Weight 446.477
Exact Mass 446.126007
PSA 152.65000
LogP 2.36
Index of Refraction 1.598

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FB3955000
CHEMICAL NAME :
Carbamic acid, ((2-((methoxyacetyl)amino)-4-(phenylthio)phenyl)carbo nimidoyl)bis-, dimethyl ester
CAS REGISTRY NUMBER :
58306-30-2
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C20-H22-N4-O6-S
MOLECULAR WEIGHT :
446.52
WISWESSER LINE NOTATION :
1OVNUYMVO1&MR DSR& BMV1O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10605 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22
RIDADR NONH for all modes of transport
RTECS FB3955000

 Synthetic Route

1,3-Bis(methoxycarbonyl)-2-methyl-2-thiopseudoeura structure

1,3-Bis(methoxy...

CAS#:34840-23-8

N-[2-amino-5-(phenylthio)phenyl]-2-methoxyacetamide structure

N-[2-amino-5-(p...

CAS#:58306-67-5

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Febantel Structure

Febantel

CAS#:58306-30-2

Literature: FR2270861DE2423679 , ; Chem.Abstr., , vol. 84, # 73949

 Precursor & DownStream

Precursor  2

DownStream  0

 Articles25

More Articles
Efficacy of a combination of febantel, pyrantel, and praziquantel for the treatment of kittens experimentally infected with Giardia species.

J. Feline Med. Surg. 8(1) , 7-13, (2006)

This study evaluated the effect of two combination products containing febantel, pyrantel, and praziquantel (FPP) for the treatment of Giardia species in experimentally infected kittens. In experiment...

Efficacy of pyrantel embonate, febantel and praziquantel against Giardia species in naturally infected adult dogs.

Vet. Rec. 150(6) , 184-6, (2002)

Rapid determination of the antiparasitic drugs flubendazole and febantel in feeds by HPLC with ultraviolet detection.

J. Pharm. Biomed. Anal. 38(2) , 375-9, (2005)

A rapid and very effective analytical procedure for the simultaneous HPLC determination of two anthelmintics, Flubendazole (FLUB) and Febantel (FEBA), in swine and poultry feeds was developed and test...

 Synonyms

{(Z)-({2-[(Méthoxyacétyl)amino]-4-(phénylsulfanyl)phényl}amino)[(méthoxycarbonyl)amino]méthylène}carbamate de méthyle
Dimethyl [[2-(2-Methoxyacetamido)-4-(phenylthio)phenyl]imidocarbonyl]dicarbamate
Carbamic acid, N,N'-[[2-[(2-methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]bis-, dimethyl ester
Dimethyl [({2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}amino)methylylidene]biscarbamate
Methyl-[N'-{2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}-N-(methoxycarbonyl)carbamimidoyl]carbamat
Bay h 5757
FEBANTEL PESTANAL
Febantel
Methyl {(Z)-({2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}amino)[(methoxycarbonyl)amino]methylene}carbamate
rintal
methyl [N'-{2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}-N-(methoxycarbonyl)carbamimidoyl]carbamate (non-preferred name)
EINECS 261-205-0
[[2-[(Methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]biscarbamic Acid Dimethyl Ester
Methyl-{(Z)-({2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}amino)[(methoxycarbonyl)amino]methylen}carbamat
Bay h-5757
MFCD01738527
bayvh5757
Methyl [N'-{2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}-N-(methoxycarbonyl)carbamimidoyl]carbamate
2-Acetamido-5-nitrothiazole VETRANAL
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Chemsrc provides Febantel(CAS#:58306-30-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Febantel are included as well.>> amp version: Febantel

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