PKUMDL WQ 2201

Modify Date: 2024-01-12 17:37:44

PKUMDL WQ 2201 structure	Common Name	PKUMDL WQ 2201
	CAS Number	592474-91-4	Molecular Weight	351.808
	Density	1.4±0.1 g/cm3	Boiling Point	523.5±60.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₄ClN₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	270.4±32.9 °C

Use of PKUMDL WQ 2201

PKUMDL-WQ-2201 is a PHGDH non-NAD+-competing allosteric inhibitor (IC50=35.7 μM). PKUMDL-WQ-2201 also inhibits PHGDH mutants with IC50s of 69 μM (T59A) and >300 μM (T56AK57A), respectively. PKUMDL-WQ-2201 inhibits de novo serine synthesis in cancer cells, and reduces tumor growth[1][2].

Name	PKUMDL-WQ-2201
Synonym	More Synonyms

Description	PKUMDL-WQ-2201 is a PHGDH non-NAD+-competing allosteric inhibitor (IC50=35.7 μM). PKUMDL-WQ-2201 also inhibits PHGDH mutants with IC50s of 69 μM (T59A) and >300 μM (T56AK57A), respectively. PKUMDL-WQ-2201 inhibits de novo serine synthesis in cancer cells, and reduces tumor growth[1][2].
Related Catalog	Research Areas >> Cancer
Target	IC50: 35.7 μM (PHGDH WT), 69 μM (PHGDH T59A), >300 μM (PHGDH T56AK57A)[1]
In Vitro	PKUMDL-WQ-2201 (10 nM-100 μM; 3 d) 对 PHGDH 扩增的乳腺癌细胞系具有良好的选择性和抑制作用，EC50 值分别为 7.7 μM (MDA-MB-468) 和 10.8 μM (HCC70)[1]。
In Vivo	PKUMDL-WQ-2201 (5-20 mg/kg; 腹腔注射; 每天 1 次, 共 30 天) 与对照组小鼠相比，对 MDA-MB-468 异种移植有显著的抑制作用，但不影响肿瘤生长[1]。
References	[1]. Wang Q, et al. Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Cell Chem Biol. 2017 Jan 19;24(1):55-65. [2]. Zhao JY, et al. A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism. Eur J Med Chem. 2021 May 5;217:113379.

Density	1.4±0.1 g/cm3
Boiling Point	523.5±60.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₄ClN₃O₃S
Molecular Weight	351.808
Flash Point	270.4±32.9 °C
Exact Mass	351.044434
LogP	2.79
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.647

2-Chloro-4-(5-{[(ethylcarbamothioyl)hydrazono]methyl}-2-furyl)benzoic acid

Benzoic acid, 2-chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]-

PKUMDL-WQ-2201

2-chloro-4-(5-{2-[(ethylamino)carbothioyl]carbohydrazonoyl}-2-furyl)benzoic acid

2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]-benzoic acid

DC Chemicals Limited
China
Product Name: PKUMDL-WQ-2201
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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