Hydroxocobalamin monohydrochloride
Modify Date: 2024-01-05 20:03:52
Hydroxocobalamin monohydrochloride structure
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Common Name | Hydroxocobalamin monohydrochloride | ||
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| CAS Number | 59461-30-2 | Molecular Weight | 1381.81 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C62H89ClCoN13O15P | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Hydroxocobalamin monohydrochlorideHydroxocobalamin hydrochloride (Vitamin B12a hydrochloride) is a naturally occurring vitamin B12 form found in food and used as a dietary supplement in the treatment of vitamin B12 deficiency. |
| Name | aquocobalamin chloride |
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| Synonym | More Synonyms |
| Description | Hydroxocobalamin hydrochloride (Vitamin B12a hydrochloride) is a naturally occurring vitamin B12 form found in food and used as a dietary supplement in the treatment of vitamin B12 deficiency. |
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| Related Catalog | |
| In Vitro | The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide and hydroxocobalamin attenuates vascular responses to NO in vitro[1]. |
| In Vivo | Treatment with hydroxocobalamin before or after giving LPS attenuates LPS-induced hypotension and increases in plasma RNI and enhances LPS-induced urinary excretion of RNI. Hydroxocobalamin (20 mg/kg i.p.) given to Swiss-Webster mice 30 min before giving LPS (16 mg/kg i.p.) decreases the 24-hr mortality of LPS from 80 to 50% and the 36- and 96-hr mortality from 100 to 60% (hydroxocobalamin)[1]. Hydroxocobalamin is widely used and seems to be the antidote of choice when acute cyanide poisoning is suspected. In rats receiving hydroxocobalamin and hyperbaric oxygen therapy , respiration improve and cyanosis disappear, with subsequent stabilization of mean arterial blood pressure. These findings indicate that a combined administration of hydroxocobalamin and hyperbaric oxygen therapy has a beneficial and persistent effect on the cerebral metabolism during cyanide intoxication[2]. Repeated administration of hydroxocobalamin is devoid of significant diaphragmatic and cardiac muscle toxicity and therefore remains a safe antidote for acute cyanide poisoning[3]. More than 60% of the mice administered 35 mg/kg (0.63 mmol/kg) of NaSH (LD90) survive (at 24 h) when hydroxocobalamin (0.25 mmol/kg) is given after NaSH administration whereas less than 15% of the mice survive without hydroxocobalamin. Hydroxocobalamin (50–100 μM) or cobalt (50–100 μM) also preventes hepatocyte cytotoxicity induced by NaSH (500 μM). Furthermore, adding hydroxocobalamin 60 min later than NaSH still shows some protective activity[4]. |
| Animal Admin | Rats: Rats are pretreated with sterile PBS (0.1 mL/kg i.v.) 30 min before administration of LPS (0.8 mg/kg i.v.). Fifteen minutes after administration of LPS, when the 125-mediated decrease in blood pressure is maximum, the rats are administered either PBS (0.1 mI/kg i.v.) or hydroxocobalamin (20-30 mg/kg i.v.). Blood pressure, heart rate and RNI are measured[1]. Mice: Adult male CD1 mice, 25-30 g body weight are allowed to acclimatize for at least 7 days prior to experiment on standard chip bedding. All animals are fed ad libitum and are not fasted before experiments. Mice are treated with 0.1 mL/25 g volume per weight ratio of single injection. The survival of animals is recorded 24 h after the treatment[4]. |
| References |
| Molecular Formula | C62H89ClCoN13O15P |
|---|---|
| Molecular Weight | 1381.81 |
| PSA | 432.85000 |
| LogP | 7.23660 |
| Storage condition | 2-8°C |
| Water Solubility | methanol: soluble10mg/mL at 20°C, clear, dark red |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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In vivo doses of butadiene epoxides as estimated from in vitro enzyme kinetics by using cob(I)alamin and measured hemoglobin adducts: an inter-species extrapolation approach.
Toxicol. Appl. Pharmacol. 281(3) , 276-84, (2014) 1,3-Butadiene (BD) is a rodent and human carcinogen. In the cancer tests, mice have been much more susceptible than rats with regard to BD-induced carcinogenicity. The species-differences are dependen... |
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Production benefits from pre- and post-lambing anthelmintic treatment of ewes on commercial farms in the southern North Island of New Zealand.
N. Z. Vet. J. 63 , 211-9, (2015) To measure the magnitude and variability in production responses to anthelmintic treatments administered to adult ewes around lambing.Ewes carrying twin lambs, from sheep and beef farms (eight in Year... |
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Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product.
Mol. Genet. Metab. 97 , 260-266, (2009) The MMACHC gene product of the cblC complementation group, referred to as the cblC protein, catalyzes the in vitro and in vivo decyanation of cyanocobalamin (vitamin B(12)). We hypothesized that the c... |
| hydroxocobalamin hydrochloride |
| cobalt [(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2S)-1-[3-[(2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] phosphate hydrate hydrochloride |