ethyl 4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-1,4-dihydropyrimidine-5-carboxylate

Modify Date: 2025-09-25 00:09:51

ethyl 4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-1,4-dihydropyrimidine-5-carboxylate structure	Common Name	ethyl 4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-1,4-dihydropyrimidine-5-carboxylate
	CAS Number	5948-75-4	Molecular Weight	322.38
	Density	1.3±0.1 g/cm3	Boiling Point	462.4±55.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₈N₂O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	233.5±31.5 °C

Use of ethyl 4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-1,4-dihydropyrimidine-5-carboxylate

gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC50 of 2.2 µM and CC50 of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells[1].

Name	Ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-sulfanyl-1,4-dihydropyrimidine-5-carboxylate
Synonym	More Synonyms

Description	gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC50 of 2.2 µM and CC50 of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Inflammation/Immunology
Target	HIV-1:2.2 μM (IC50) HIV-1:100.90 μM (CC50)
References	[1]. Senapathi J, et al. Design, Synthesis, and Antiviral activity of 1,2,3,4-Tetrahydropyrimidine derivatives acting as novel entry inhibitors to target at "Phe43 cavity" of HIV-1 gp120. Bioorg Med Chem. 2021 Dec 15;52:116526.

Density	1.3±0.1 g/cm3
Boiling Point	462.4±55.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₈N₂O₄S
Molecular Weight	322.38
Flash Point	233.5±31.5 °C
Exact Mass	322.098724
LogP	1.88
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.633
InChIKey	PXLULCMFZZNMDQ-UHFFFAOYSA-N
SMILES	CCOC(=O)C1=C(C)NC(=S)NC1c1ccc(O)c(OC)c1

Name: Vasodilating activity in Wistar rat aortic rings assessed as reduction in phenylephri...
Source: ChEMBL
Target: Aorta
External Id: CHEMBL4414681

Name: Vasodilating activity in Wistar rat aortic rings assessed as reduction in phenylephri...
Source: ChEMBL
Target: Aorta
External Id: CHEMBL4414682

Name: Vasodilating activity in Wistar rat aortic rings assessed as reduction in KCl-induced...
Source: ChEMBL
Target: Aorta
External Id: CHEMBL4414683

Name: Vasodilating activity in Wistar rat aortic rings assessed as reduction in KCl-induced...
Source: ChEMBL
Target: Aorta
External Id: CHEMBL4414684

Name: Inhibition of HIV1 gp120 interaction with CD4 in human SUP-T1 cells expressing CCR5, ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5055346

Name: Antiviral activity against HIV1 931N101 infected in human SupT1 cells assessed as inh...
Source: ChEMBL
Target: Human immunodeficiency virus 1
External Id: CHEMBL5055345

Name: Cytotoxicity against human SUP-T1 cells assessed as reduction in cell viability measu...
Source: ChEMBL
Target: SUP-T1
External Id: CHEMBL5055344

Name: Antiviral activity against HIV1 931N101 infected in human SupT1 cells assessed as inh...
Source: ChEMBL
Target: Human immunodeficiency virus 1
External Id: CHEMBL5055343

Name: Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL2015032

Name: Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay
Source: ChEMBL
Target: U-251
External Id: CHEMBL2015031

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Ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-, ethyl ester

5-pyrimidinecarboxylic acid, 1,4-dihydro-4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-, ethyl ester

5-pyrimidinecarboxylic acid, 1,6-dihydro-6-(4-hydroxy-3-methoxyphenyl)-2-mercapto-4-methyl-, ethyl ester

ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Ethyl 6-(4-hydroxy-3-methoxyphenyl)-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate

MFCD02331148

Ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-sulfanyl-1,4-dihydropyrimidine-5-carboxylate

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ethyl 4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-1,4-dihydropyrimidine-5-carboxylate

Use of ethyl 4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-1,4-dihydropyrimidine-5-carboxylate

Names

Biological Activity

Chemical & Physical Properties

Bioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.