20α,22R-Dihydroxycholesterol

Modify Date: 2025-08-25 13:58:05

20α,22R-Dihydroxycholesterol Structure
20α,22R-Dihydroxycholesterol structure
Common Name 20α,22R-Dihydroxycholesterol
CAS Number 596-94-1 Molecular Weight 418.652
Density 1.1±0.1 g/cm3 Boiling Point 553.5±25.0 °C at 760 mmHg
Molecular Formula C27H46O3 Melting Point N/A
MSDS N/A Flash Point 233.1±17.8 °C

 Use of 20α,22R-Dihydroxycholesterol


20α,22R-Dihydroxycholesterol is an endogenous metabolic intermediate. 20α,22R-Dihydroxycholesterol involved in the biosynthesis of cholesterol to steroid hormones[1].

 Names

Name (20R,22R)-20,22-dihydroxycholesterol
Synonym More Synonyms

 20α,22R-Dihydroxycholesterol Biological Activity

Description 20α,22R-Dihydroxycholesterol is an endogenous metabolic intermediate. 20α,22R-Dihydroxycholesterol involved in the biosynthesis of cholesterol to steroid hormones[1].
Related Catalog
References

[1]. Mast N, et, al. Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. J Biol Chem. 2011 Feb 18;286(7):5607-13.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 553.5±25.0 °C at 760 mmHg
Molecular Formula C27H46O3
Molecular Weight 418.652
Flash Point 233.1±17.8 °C
Exact Mass 418.344696
PSA 60.69000
LogP 5.98
Vapour Pressure 0.0±3.4 mmHg at 25°C
Index of Refraction 1.550
InChIKey ISBSSBGEYIBVTO-TYKWNDPBSA-N
SMILES CC(C)CCC(O)C(C)(O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C

 20α,22R-DihydroxycholesterolBioassay

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Name: Binding affinity to ecdysone receptor ligand binding domain in Drosophila melanogaste...
Source: ChEMBL
Target: Ecdysone receptor
External Id: CHEMBL1051107
Name: Displacement of [3H]-25-OHC from human OSBP overexpressed in HEK293T cell lysate asse...
Source: ChEMBL
Target: Oxysterol-binding protein 1
External Id: CHEMBL5320826
Name: Displacement of [3H]-25-OHC from human ORP4 overexpressed in HEK293T cell lysate asse...
Source: ChEMBL
Target: Oxysterol-binding protein 2
External Id: CHEMBL5320827
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 Synonyms

20α,22R-Dihydroxycholesterol
(22R)-20α,22-Dihydroxycholesterol
Oxy-16
20,22-dihydroxycholesterol
(3β,22R)-Cholest-5-ene-3,20,22-triol
(20R,22R)-20,22-Dihydroxycholesterol
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