D-Hydroorotic Acid
D-Hydroorotic Acid structure
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Common Name | D-Hydroorotic Acid | ||
|---|---|---|---|---|
| CAS Number | 5988-53-4 | Molecular Weight | 158.11200 | |
| Density | 1.523 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C5H6N2O4 | Melting Point | 255ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
| Name | (4R)-2,6-dioxo-1,3-diazinane-4-carboxylic acid |
|---|---|
| Synonym | More Synonyms |
| Density | 1.523 g/cm3 |
|---|---|
| Melting Point | 255ºC (dec.)(lit.) |
| Molecular Formula | C5H6N2O4 |
| Molecular Weight | 158.11200 |
| Exact Mass | 158.03300 |
| PSA | 95.50000 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
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The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.
Biochemistry 47(34) , 8929-36, (2008) Inhibitors of dihydroorotate dehydrogenase (DHODH) have been suggested for the treatment of rheumatoid arthritis, psoriasis, autoimmune diseases, Plasmodium, and bacterial and fungal infections. Here ... |
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Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH.
Hum. Mol. Genet. 21(18) , 3969-83, (2012) Biallelic mutations in the gene encoding DHOdehase [dihydroorotate dehydrogenase (DHODH)], an enzyme required for de novo pyrimidine biosynthesis, have been identified as the cause of Miller (Genée-We... |
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Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase fromToxoplasma gondii
Mol. Biochem. Parasitol. 184(2) , 71-81, (2012) Graphical abstract Toxoplasma gondii dihydroorotate dehydrogenase is an essential mitochondrial enzyme that exhibits inhibitor sensitivities distinct from those of the human and Plasmodium falciparum ... |
| Hydroorotic acid D-form |
| UNII-WXS4GY9Q24 |
| D-4,5-dihydroorotic acid |
| MFCD01862150 |
| Dihydro-D-orotic acid |
| R-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid |
| Hydroorotic acid,D |
| 4,5-dihydro-D-orotic acid |
| D-Hydroorotic acid |