HPI-1
Modify Date: 2024-01-05 21:51:31
HPI-1 structure
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Common Name | HPI-1 | ||
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| CAS Number | 599150-20-6 | Molecular Weight | 463.522 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 638.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C27H29NO6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 339.8±31.5 °C | |
Use of HPI-1GLI antagonist-1 is a potent GLI antagonist with an IC50 value of 1.1 µM. GLI antagonist-1 shows anti-proliferative activity. GLI antagonist-1 decreases the GLI1 mRNA expression. GLI antagonist-1 inhibits colony formation in a dose-dependent manner[1]. |
| Name | 2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate |
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| Synonym | More Synonyms |
| Description | GLI antagonist-1 is a potent GLI antagonist with an IC50 value of 1.1 µM. GLI antagonist-1 shows anti-proliferative activity. GLI antagonist-1 decreases the GLI1 mRNA expression. GLI antagonist-1 inhibits colony formation in a dose-dependent manner[1]. |
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| Related Catalog | |
| Target |
IC50: 1.1 µM (GLI)[1] |
| In Vitro | GLI antagonist-1 (compound HPI-1) (0-25 µM; 72 h) shows anti-proliferative activity with IC50 values of 29, >25, 20.5 µM for SUM149, MDA-MB-231, SUM159 cells, respectively[1]. GLI antagonist-1 (10 µM; 72 h) decreases the GLI1 mRNA expression in SUM149 cells[1]. GLI antagonist-1 (5, 10, 20 µM) inhibits colony formation in a dose-dependent manner in SUM149 and MDA-MB-231 cells[1]. Cell Proliferation Assay[1] Cell Line: SUM149, MDA-MB-231, SUM159 cells Concentration: 0-25 µM Incubation Time: 72 h Result: Showed anti-proliferative activity with IC50 values of 29, >25, 20.5 µM for SUM149, MDA-MB-231, SUM159 cells, respectively. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 638.2±55.0 °C at 760 mmHg |
| Molecular Formula | C27H29NO6 |
| Molecular Weight | 463.522 |
| Flash Point | 339.8±31.5 °C |
| Exact Mass | 463.199493 |
| PSA | 94.09000 |
| LogP | 2.18 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.620 |
| HS Code | 2933499090 |
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| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate |
| 3-Quinolinecarboxylic acid, 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-, 2-methoxyethyl ester |
| 2-methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate |