Veratramine

Modify Date: 2026-07-02 13:32:20

Veratramine structure	Common Name	Veratramine
	CAS Number	60-70-8	Molecular Weight	409.604
	Density	1.1±0.1 g/cm3	Boiling Point	565.0±50.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₃₉NO₂	Melting Point	122-124ºC
	MSDS	N/A	Flash Point	86.2±20.7 °C

Use of Veratramine

Veratramine(NSC17821; NSC23880) is useful as a signal transduction inhibitor for treating tumors.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Veratramine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Veratramine(NSC17821; NSC23880) is useful as a signal transduction inhibitor for treating tumors.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Alkaloid
References	[1]. Wang L, et al. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie. 2008 Aug;63(8):606-10. [2]. Li HJ, et al. Puqienine F, a novel veratramine alkaloid from the bulbs of Fritillaria puqiensis. Chem Pharm Bull (Tokyo). 2006 May;54(5):722-4.

Description

Veratramine(NSC17821; NSC23880) is useful as a signal transduction inhibitor for treating tumors.

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

Natural Products >> Alkaloid

References

[1]. Wang L, et al. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie. 2008 Aug;63(8):606-10.

[2]. Li HJ, et al. Puqienine F, a novel veratramine alkaloid from the bulbs of Fritillaria puqiensis. Chem Pharm Bull (Tokyo). 2006 May;54(5):722-4.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.1±0.1 g/cm3
Boiling Point	565.0±50.0 °C at 760 mmHg
Melting Point	122-124ºC
Molecular Formula	C₂₇H₃₉NO₂
Molecular Weight	409.604
Flash Point	86.2±20.7 °C
Exact Mass	409.298065
PSA	52.49000
LogP	4.90
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.601
InChIKey	MALFODICFSIXPO-KFKQDBFTSA-N
SMILES	Cc1c(C(C)C2NCC(C)CC2O)ccc2c1CC1C2CC=C2CC(O)CCC21C

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YX5094000

CHEMICAL NAME :: Veratramine

CAS REGISTRY NUMBER :: 60-70-8

BEILSTEIN REFERENCE NO. :: 0055515

LAST UPDATED :: 199706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C27-H39-N-O2

MOLECULAR WEIGHT :: 409.67

WISWESSER LINE NOTATION :: L D6 B566 LU&TTTJ A1 E1 OQ FY1&- BT6MTJ CQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,89,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 2,418,1953

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 3,175,1970 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 16700 ug/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 136,1174,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 29 mg/kg

SEX/DURATION :: female 13-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 123,921,1966 *** REVIEWS *** TOXICOLOGY REVIEW LYPHAD Lyon Pharmaceutique. (Medipharly, 12, rue de la Barre, 69002 Lyons, France) V.1- 1950- Volume(issue)/page/year: 26,5,1975

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Assays to identify small molecules inhibitory for eIF4E expression
Source: 13133
Target: N/A
External Id: 20160513eIF4E

Name: Antimigratory activity against Homo sapiens (human) PC3 cells at 50 uM after 24 hr by...
Source: ChEMBL
Target: PC-3
External Id: CHEMBL3074816

Name: Antiproliferative activity against Homo sapiens (human) PC3 cells at 50 uM after 72 h...
Source: ChEMBL
Target: PC-3
External Id: CHEMBL3074819

Name: Inhibition of electric eel AChE at 2 mg/ml by Ellman's method
Source: ChEMBL
Target: Acetylcholinesterase
External Id: CHEMBL2166270

Name: Inhibition of horse BChE at 2 mg/ml by Ellman's method
Source: ChEMBL
Target: Cholinesterase
External Id: CHEMBL2166271

Name: NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L...
Source: DTP/NCI
Target: N/A
External Id: MCF7_OneDose

Name: Cytotoxicity against african green monkey Vero cells
Source: ChEMBL
Target: Vero
External Id: CHEMBL1026712

Name: NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell...
Source: DTP/NCI
Target: N/A
External Id: IGROV1_OneDose

Name: Inhibition of human BChE by Ellman's method
Source: ChEMBL
Target: Cholinesterase
External Id: CHEMBL2166019

Name: Inhibition of electric eel AChE by Ellman's method
Source: ChEMBL
Target: Acetylcholinesterase
External Id: CHEMBL2166020

Total 12, Current Page 1 of 2

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Veratramine

(3β,23R)-14,15,16,17-Tetradehydroveratraman-3,23-diol

Vreaframine

(3b,23b)-14,15,16,17-Tetradehydroveratraman-3,23-diol

veratraMin

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of Veratramine?

A: CAS number of Veratramine is 60-70-8.

Q: What is the English name of Veratramine?

A: The English name of Veratramine is Veratramine.

Q: What is the molecular formula of Veratramine?

A: Molecular formula of Veratramine is C27H39NO2.

Q: What is the molecular weight of Veratramine?

A: Molecular weight of Veratramine is 409.604.

Q: What is the SMILES notation of Veratramine?

A: SMILES notation of Veratramine is Cc1c(C(C)C2NCC(C)CC2O)ccc2c1CC1C2CC=C2CC(O)CCC21C.

Q: What are the uses of Veratramine?

A: Main uses of Veratramine: Veratramine(NSC17821; NSC23880) is useful as a signal transduction inhibitor for treating tumors.

Q: What is the boiling point of Veratramine?

A: Boiling point of Veratramine is 565.0±50.0 °C at 760 mmHg.

Q: What is the InChIKey of Veratramine?

A: InChIKey of Veratramine is MALFODICFSIXPO-KFKQDBFTSA-N.

Q: What is the polar surface area (PSA) of Veratramine?

A: Polar surface area (PSA) of Veratramine is 52.49000.

Q: What is the melting point of Veratramine?

A: Melting point of Veratramine is 122-124ºC.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

BioBioPha

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Product Name: Veratramine
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Price: $66/10mM*1mLinDMSO

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Veratramine

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