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China
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China
Product Name: Veratramine
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60-70-8

60-70-8 structure

60-70-8 structure

Name: Veratramine
Chemical Name: Veratramine
CAS Number: 60-70-8
Molecular Formula: C₂₇H₃₉NO₂
Molecular Weight: 409.604
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Methylpyridine
Create Date: 2018-07-18 13:50:12
Modify Date: 2026-07-02 13:32:20
Veratramine(NSC17821; NSC23880) is useful as a signal transduction inhibitor for treating tumors.

Name	Veratramine
Synonyms	Veratramine (NSC17821 (3,23)-14,15,16,17-Teradehydroveratraman-3,23-diol NSC17821;NSC23880 Veratramine, 10 mM in DMSO 5S-methyl-2S-[1S-[2,3S,4,6,6,11,11aS,11bR-octahydro-3R-hydroxy-10,11b-dimethyl-1H-benzo[a]fluoren-9-yl]ethyl]-3-piperidinol (2S,3R,5S)-2-((S)-1-((3S,6,11aS,11bR)-3-Hydroxy-10,11b-dimethyl-2,3,4,6,6a,11,11a,11b-octahydro-1H-benzo[a]fluoren-9-yl)ethyl)-5-methylpiperidin-3-ol (3b,23b)-14,15,16,17-Tetradehydroveratraman-3,23-diol Veratramine-RM (2S,3R,5S)-5-Methyl-2-[(1S)-1-[(3S,6,11aS,11bR)-2,3,4,6,6a,11,11a,11b-octahydro-3-hydroxy-10,11b-dimethyl-1H-benzo[a]fluoren-9-yl]ethyl]-3-piperidinol Veratramine -8 veratramine AIDS011940 (2S,3R,5S)-2-[(1S)-1-[(3S,6,11aS,11bR)-3-hydroxy-10,11b-dimethyl-1,2,3,4,6,6a,11,11a-octahydrobenzo[a]fluoren-9-yl]ethyl]-5-methylpiperidin-3-ol veratraMin (3b,23b)-14,15,16,17-Teradehydroveratraman-3,23-diol 14,15,16,17-Tetradehydroveratraman-3β,23β-diol Veratramine(P) 3-Piperidinol, 5-methyl-2-[(1S)-1-[(3S,6,11aS,11bR)-2,3,4,6,6a,11,11a,11b-octahydro-3-hydroxy-10,11b-dimethyl-1H-benzo[a]fluoren-9-yl]ethyl]-, (2S,3R,5S) Veratramine (NSC-23880) (3β,23R)-14,15,16,17-Tetradehydroveratraman-3,23-diol Vreaframine Veratramine from Veratrum nium L Veratramine Veratramine

Description	Veratramine(NSC17821; NSC23880) is useful as a signal transduction inhibitor for treating tumors.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Alkaloid
References	[1]. Wang L, et al. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie. 2008 Aug;63(8):606-10. [2]. Li HJ, et al. Puqienine F, a novel veratramine alkaloid from the bulbs of Fritillaria puqiensis. Chem Pharm Bull (Tokyo). 2006 May;54(5):722-4.

Density	1.1±0.1 g/cm3
Boiling Point	565.0±50.0 °C at 760 mmHg
Melting Point	122-124ºC
Molecular Formula	C₂₇H₃₉NO₂
Molecular Weight	409.604
Flash Point	86.2±20.7 °C
Exact Mass	409.298065
PSA	52.49000
LogP	4.90
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.601

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YX5094000

CHEMICAL NAME :: Veratramine

CAS REGISTRY NUMBER :: 60-70-8

BEILSTEIN REFERENCE NO. :: 0055515

LAST UPDATED :: 199706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C27-H39-N-O2

MOLECULAR WEIGHT :: 409.67

WISWESSER LINE NOTATION :: L D6 B566 LU&TTTJ A1 E1 OQ FY1&- BT6MTJ CQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,89,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 2,418,1953

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 3,175,1970 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 16700 ug/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 136,1174,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 29 mg/kg

SEX/DURATION :: female 13-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 123,921,1966 *** REVIEWS *** TOXICOLOGY REVIEW LYPHAD Lyon Pharmaceutique. (Medipharly, 12, rue de la Barre, 69002 Lyons, France) V.1- 1950- Volume(issue)/page/year: 26,5,1975

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