5-Nitro-1,2-dihydroacenaphthylene

Modify Date: 2024-01-12 10:30:51

5-Nitro-1,2-dihydroacenaphthylene Structure
5-Nitro-1,2-dihydroacenaphthylene structure
 Common Name 5-Nitro-1,2-dihydroacenaphthylene
CAS Number 602-87-9 Molecular Weight 199.205
Density 1.4±0.1 g/cm3 Boiling Point 377.5±21.0 °C at 760 mmHg
Molecular Formula C12H9NO2 Melting Point 100-101 °C(lit.)
MSDS Chinese USA Flash Point 191.8±14.9 °C
Symbol GHS08
GHS08		 Signal Word Danger

 Names

Name 5-Nitroacenaphthene
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 377.5±21.0 °C at 760 mmHg
Melting Point 100-101 °C(lit.)
Molecular Formula C12H9NO2
Molecular Weight 199.205
Flash Point 191.8±14.9 °C
Exact Mass 199.063324
PSA 45.82000
LogP 3.92
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.724
Stability Stable. Combustible. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AB1060000
CHEMICAL NAME :
Acenaphthene, 5-nitro-
CAS REGISTRY NUMBER :
602-87-9
BEILSTEIN REFERENCE NO. :
1876864
LAST UPDATED :
199701
DATA ITEMS CITED :
23
MOLECULAR FORMULA :
C12-H9-N-O2
MOLECULAR WEIGHT :
199.22
WISWESSER LINE NOTATION :
L566 1A LT&&J HNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
40 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
33 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Reproductive - Tumorigenic effects - ovarian tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3744 mg/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
120 gm/kg/17W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
60 gm/kg/70W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Reproductive - Tumorigenic effects - ovarian tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
61 gm/kg/17W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - mouse Liver
DOSE/DURATION :
200 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 190,159,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,319,1978 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,319,1978 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H350
Precautionary Statements P201-P308 + P313
Personal Protective Equipment Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T,Xi
Risk Phrases R45
Safety Phrases S53-S45
RIDADR 2811
WGK Germany 3
RTECS AB1060000
HS Code 2904209090

 Synthetic Route

Acenaphthene structure

Acenaphthene

CAS#:83-32-9

~89%

5-Nitro-1,2-dihydroacenaphthylene Structure

5-Nitro-1,2-dih...

CAS#:602-87-9
Literature: Khosravi; Moradian; Gharanjig; Afshar Taromi Journal of the Chinese Chemical Society, 2005 , vol. 52, # 3 p. 495 - 502
Acenaphthene structure

Acenaphthene

CAS#:83-32-9

~%

Acenaphthylene,1,2-dihydro-3-nitro- structure

Acenaphthylene,...

CAS#:3807-77-0
5-Nitro-1,2-dihydroacenaphthylene Structure

5-Nitro-1,2-dih...

CAS#:602-87-9
Literature: Russian Chemical Bulletin, , vol. 43, # 3 p. 507 - 508 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 3 p. 547 - 548
(6-Amino-1,2-dihydro-5-acenaphthylenyl)(hydroxy)azane oxide structure

(6-Amino-1,2-di...

CAS#:61631-80-9

~%

5-Nitro-1,2-dihydroacenaphthylene Structure

5-Nitro-1,2-dih...

CAS#:602-87-9
Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 13, p. 568 - 571 Zhurnal Organicheskoi Khimii, , vol. 13, # 3 p. 620 - 624
Diethyl ether structure

Diethyl ether

CAS#:60-29-7
Acenaphthene structure

Acenaphthene

CAS#:83-32-9

~%

5-Nitro-1,2-dihydroacenaphthylene Structure

5-Nitro-1,2-dih...

CAS#:602-87-9
Literature: Gazzetta Chimica Italiana, , vol. 66, p. 31,36, 126
Acenaphthene structure

Acenaphthene

CAS#:83-32-9
acetic acid structure

acetic acid

CAS#:64-19-7

~%

5-Nitro-1,2-dihydroacenaphthylene Structure

5-Nitro-1,2-dih...

CAS#:602-87-9
Literature: Gazzetta Chimica Italiana, , vol. 66, p. 31,36, 126
Acenaphthene structure

Acenaphthene

CAS#:83-32-9
benzene structure

benzene

CAS#:71-43-2

~%

5-Nitro-1,2-dihydroacenaphthylene Structure

5-Nitro-1,2-dih...

CAS#:602-87-9
Literature: Gazzetta Chimica Italiana, , vol. 66, p. 31,36, 126
nitric acid structure

nitric acid

CAS#:7697-37-2
Ethanoic anhydride structure

Ethanoic anhydride

CAS#:108-24-7
Acenaphthene structure

Acenaphthene

CAS#:83-32-9

~%

Acenaphthylene,1,2-dihydro-3-nitro- structure

Acenaphthylene,...

CAS#:3807-77-0
Detail
Literature: Journal of the Society of Chemical Industry, London, , vol. 49, p. 413 T, 421 T Journal of Organic Chemistry, , vol. 24, p. 214,218
nitric acid structure

nitric acid

CAS#:7697-37-2
Acenaphthene structure

Acenaphthene

CAS#:83-32-9
acetic acid structure

acetic acid

CAS#:64-19-7

~%

5-Nitro-1,2-dihydroacenaphthylene Structure

5-Nitro-1,2-dih...

CAS#:602-87-9
Literature: Bulletin de la Societe Chimique de France, , vol. <2> 48, p. 755 Chemische Berichte, , vol. 20, p. 610 Chemische Berichte, , vol. 21, p. 1455

 Customs

HS Code 2904209090
Summary 2904209090 derivatives containing only nitro or only nitroso groups。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Articles2

More Articles
5-Nitroacenaphthene: a newly recognized role for the nitro function in mutagenicity.

Environ. Mutagen. 5(1) , 17-22, (1983)

The direct-acting mutagenicity of 5-nitroacenaphthene for Salmonella typhimurium is dependent upon the reduction of the nitro function as evidenced by the significant decrease in mutagenicity seen wit...
Identification of mutagenic metabolites formed by C-hydroxylation and nitroreduction of 5-nitroacenaphthene in rat liver.

Cancer Res. 42(4) , 1243-8, (1982)

The metabolism of the mutagen and carcinogen, 5-nitroacenaphthene, by the 9000 x g supernatant from the livers of Aroclor-pretreated rats was studied. The major primary metabolites were 1-hydroxy-5-ni...

 Synonyms

EINECS 210-025-0
Acenaphthylene, 1,2-dihydro-5-nitro-
5-Nitro-1,2-dihydroacenaphthylene
MFCD00014277
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