7,8-Benzoflavone

Modify Date: 2024-01-02 17:46:03

7,8-Benzoflavone Structure
7,8-Benzoflavone structure
 Common Name 7,8-Benzoflavone
CAS Number 604-59-1 Molecular Weight 272.297
Density 1.3±0.1 g/cm3 Boiling Point 460.9±45.0 °C at 760 mmHg
Molecular Formula C19H12O2 Melting Point 153-157 °C(lit.)
MSDS USA Flash Point 215.8±22.3 °C

 Use of 7,8-Benzoflavone


Alpha-Naphthoflavone is a synthetic flavonoid, acts as a potent and competitive aromatase inhibitor with an IC50 and a Ki of 0.5 and 0.2 μM, respectively[1].

 Names

Name α-naphthoflavone
Synonym More Synonyms

 7,8-Benzoflavone Biological Activity

Description Alpha-Naphthoflavone is a synthetic flavonoid, acts as a potent and competitive aromatase inhibitor with an IC50 and a Ki of 0.5 and 0.2 μM, respectively[1].
Related Catalog
Target

IC50: 0.5 μM (Aromatase)[1] Ki: 0.2 μM (Aromatase)[1]

References

[1]. Campbell DR, et al. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol. 1993 Sep;46(3):381-8.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 460.9±45.0 °C at 760 mmHg
Melting Point 153-157 °C(lit.)
Molecular Formula C19H12O2
Molecular Weight 272.297
Flash Point 215.8±22.3 °C
Exact Mass 272.083740
PSA 30.21000
LogP 4.79
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.695
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QL6250000
CHEMICAL NAME :
4H-Naphtho(1,2-b)pyran-4-one, 2-phenyl-
CAS REGISTRY NUMBER :
604-59-1
BEILSTEIN REFERENCE NO. :
0210862
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C19-H12-O2
MOLECULAR WEIGHT :
272.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
40 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,3662,1987

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi,Xn,C,F
Risk Phrases 68-34-11
Safety Phrases S24/25-S36/37
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS QL6250000
HS Code 2914399090

 Precursor & DownStream

Precursor  0

DownStream  1

 Customs

HS Code 2914399090
Summary 2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles42

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 Synonyms

Benzo[h]flavone
2-phenylbenzo[h]chromen-4-one
4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl-
α-Naphthylflavone
2-Phenyl-4H-benzo[h]chromen-4-one
2-Phenylbenzo(h)chromen-4-one
a-Naphthylflavone
2-Phenyl-benzo[h]chromen-4-one
alpha-naphthoflavone
7,8-Benzoflavone
MFCD00004985
a-Naphthoflavone
α-Naphthoflavone
2-Phenyl-4H-naphtho[1,2-b]pyran-4-one
EINECS 210-071-1
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