Gomisin D

Modify Date: 2024-01-06 07:26:22

Gomisin D Structure
Gomisin D structure
 Common Name Gomisin D
CAS Number 60546-10-3 Molecular Weight 530.564
Density 1.3±0.1 g/cm3 Boiling Point 698.5±55.0 °C at 760 mmHg
Molecular Formula C28H34O10 Melting Point 194ºC
MSDS N/A Flash Point 229.3±25.0 °C

 Use of Gomisin D


Gomisin D, a lignan compound isolated from Fructus Schisandra, is a potential antidiabetic and anti-Alzheimer’s agent. Gomisin D inhibits UDP-Glucuronosyltransferases activity and scavenges ABTS(+) radicals. Gomisin D is used as a quality marker of Shengmai San and shenqi Jiangtang Granule[1].

 Names

Name (11S,12R,15S,24S,25S)-12,25-Dihydroxy-18,19,20-trimethoxy-11,12,24,25-tetramethyl-4,6,9,14-tetraoxapentacyclo[13.7.3.03,7.08,22.016,21]pentacosa-1(22),2,7,16,18,20-hexaen-13-one
Synonym More Synonyms

 Gomisin D Biological Activity

Description Gomisin D, a lignan compound isolated from Fructus Schisandra, is a potential antidiabetic and anti-Alzheimer’s agent. Gomisin D inhibits UDP-Glucuronosyltransferases activity and scavenges ABTS(+) radicals. Gomisin D is used as a quality marker of Shengmai San and shenqi Jiangtang Granule[1].
Related Catalog
Target

UDP-Glucuronosyltransferases[1]
References

[1]. Zheng X, et al. A Rapid UPLC-MS Method for Quantification of Gomisin D in Rat Plasma and Its Application to a Pharmacokinetic and Bioavailability Study. Molecules. 2019 Apr 10;24(7).

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 698.5±55.0 °C at 760 mmHg
Melting Point 194ºC
Molecular Formula C28H34O10
Molecular Weight 530.564
Flash Point 229.3±25.0 °C
Exact Mass 530.215210
PSA 122.14000
LogP 3.95
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.561
Storage condition 2-8℃

 Synonyms

(11S,12R,15S,24S,25S)-12,25-Dihydroxy-18,19,20-trimethoxy-11,12,24,25-tetramethyl-4,6,9,14-tetraoxapentacyclo[13.7.3.0.0.0]pentacosa-1(22),2,7,16,18,20-hexaen-13-one
(11R,12R,15S,24S,25S)-12,25-Dihydroxy-18,19,20-trimethoxy-11,12,24,25-tetramethyl-4,6,9,14-tetraoxapentacyclo[13.7.3.0.0.0]pentacosa-1(22),2,7,16,18,20-hexaen-13-one
10,15-Propano-10H-1,3,4,9-tetraoxabenzo[3,4]cycloundec[1,2-e]inden-8(5H)-one, 6,7-dihydro-7,19-dihydroxy-12,13,14-trimethoxy-6,7,18,19-tetramethyl-, (6S,7R,10S,18S,19S)-
10,15-Propano-10H-1,3,4,9-tetraoxabenzo[3,4]cycloundec[1,2-e]inden-8(5H)-one, 6,7-dihydro-7,19-dihydroxy-12,13,14-trimethoxy-6,7,18,19-tetramethyl-, (6R,7R,10S,18S,19S)-
Gomisin D
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  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng

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