Sesamin
Sesamin structure
|
Common Name | Sesamin | ||
|---|---|---|---|---|
| CAS Number | 607-80-7 | Molecular Weight | 354.353 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 504.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H18O6 | Melting Point | 122-124ºC | |
| MSDS | Chinese USA | Flash Point | 212.3±30.0 °C | |
Use of SesaminSesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | (+)-sesamin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2]. |
|---|---|
| Related Catalog | |
| Target |
delta 5 desaturase[1] |
| In Vitro | Pretreated with sesamin, Excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells was significantly attenuated[1]. |
| In Vivo | Sesamin (o.p.; 20 mg/kg/day) significantly reduces the infarct size by approximately 50% in male gerbils (60-85 g)[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 504.4±50.0 °C at 760 mmHg |
| Melting Point | 122-124ºC |
| Molecular Formula | C20H18O6 |
| Molecular Weight | 354.353 |
| Flash Point | 212.3±30.0 °C |
| Exact Mass | 354.110352 |
| PSA | 55.38000 |
| LogP | 3.32 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.623 |
| InChIKey | PEYUIKBAABKQKQ-AFHBHXEDSA-N |
| SMILES | c1cc2c(cc1C1OCC3C(c4ccc5c(c4)OCO5)OCC13)OCO2 |
| Storage condition | −20°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932999099 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
|
Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition.
Sci. Rep. 4 , 5896, (2014) Dysfunctions of the mitochondria and the ubiquitin-proteasome system, as well as generation of reactive oxygen species (ROS), are linked to many aging-related neurodegenerative disorders. However, the... |
|
|
Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.).
Mol. Biol. Rep. 39(6) , 6867-73, (2012) Metabolic transformations of two substrates for human cytochrome P450 (CYP450) 2C9, tolbutamide and diclofenac, were investigated in hepatic microsomes from Atlantic salmon (Salmo salar L.). Tolbutami... |
|
|
Influence of oral supplementation with sesamin on longevity of Caenorhabditis elegans and the host defense.
Eur. J. Nutr. 53(8) , 1659-68, (2014) Nutritional control has been proposed as a potential therapy for slowing the senescence of immune function and decreasing mortality. This study investigated whether sesamin could modify host defense s... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Sesamin |
| (7S,7’S,8R,8’R)-sesamin |
| 5,5'-(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(1,3-benzodioxole) |
| (+)-Sesamin |
| Pseudocubebin |
| d-Sesamin |
| SesameP.E. |
| SezaMin |
| FAGAROL |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of (+)-sesamin? |
| A: SMILES notation of (+)-sesamin is c1cc2c(cc1C1OCC3C(c4ccc5c(c4)OCO5)OCC13)OCO2. |
| Q: What is the molecular weight of (+)-sesamin? |
| A: Molecular weight of (+)-sesamin is 354.353. |
| Q: What is the InChIKey of (+)-sesamin? |
| A: InChIKey of (+)-sesamin is PEYUIKBAABKQKQ-AFHBHXEDSA-N. |
| Q: What English synonyms does (+)-sesamin have? |
| A: English synonyms of (+)-sesamin: Sesamin, (7S,7’S,8R,8’R)-sesamin, 5,5'-(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(1,3-benzodioxole), (+)-Sesamin, Pseudocubebin, d-Sesamin, SesameP.E., SezaMin, FAGAROL. |
| Q: What are the storage conditions for (+)-sesamin? |
| A: Storage conditions for (+)-sesamin: −20°C. |
| Q: What is the molecular formula of (+)-sesamin? |
| A: Molecular formula of (+)-sesamin is C20H18O6. |
| Q: What is the English name of (+)-sesamin? |
| A: The English name of (+)-sesamin is (+)-sesamin. |
| Q: What is the safety information for (+)-sesamin? |
| A: Safety information for (+)-sesamin: S22-S24/25. |
| Q: What is the LogP of (+)-sesamin? |
| A: LogP of (+)-sesamin is 3.32. |
| Q: What is the melting point of (+)-sesamin? |
| A: Melting point of (+)-sesamin is 122-124ºC. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Henan Tianfu Chemical Co., Ltd. |