Imidazolo-oxindole PKR inhibitor C16

Modify Date: 2024-01-13 14:39:57

Imidazolo-oxindole PKR inhibitor C16 Structure
Imidazolo-oxindole PKR inhibitor C16 structure
Common Name Imidazolo-oxindole PKR inhibitor C16
CAS Number 608512-97-6 Molecular Weight 268.294
Density 1.6±0.1 g/cm3 Boiling Point 674.6±55.0 °C at 760 mmHg
Molecular Formula C13H8N4OS Melting Point N/A
MSDS Chinese USA Flash Point 361.8±31.5 °C

 Use of Imidazolo-oxindole PKR inhibitor C16


PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures[1].

 Names

Name Imidazolo-oxindole PKR inhibitor C16
Synonym More Synonyms

 Imidazolo-oxindole PKR inhibitor C16 Biological Activity

Description PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures[1].
Related Catalog
References

[1]. Tronel C, et al. The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan;64:73-83.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 674.6±55.0 °C at 760 mmHg
Molecular Formula C13H8N4OS
Molecular Weight 268.294
Flash Point 361.8±31.5 °C
Exact Mass 268.041870
PSA 98.91000
LogP 0.80
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.851

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

(8Z)-8-(1H-imidazol-4-ylmethylidene)-6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one
(Z)-8-((1H-Imidazol-4-yl)methylene)-6H-thiazolo[5,4-e]indol-7(8H)-one
8-(1H-Imidazol-4-ylmethylene)-6,8-dihydro-thiazolo[5,4-e]indol-7-one
(8Z)-8-(1H-Imidazol-5-ylmethylene)-6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one
C16 (PKR inhibitor)
7H-Thiazolo[5,4-e]indol-7-one, 6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-, (8Z)-
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