phosphocyclocreatine

Modify Date: 2024-01-22 19:16:42

phosphocyclocreatine Structure
phosphocyclocreatine structure
Common Name phosphocyclocreatine
CAS Number 61839-19-8 Molecular Weight 223.12400
Density 2.03g/cm3 Boiling Point 481ºC at 760 mmHg
Molecular Formula C5H10N3O5P Melting Point N/A
MSDS N/A Flash Point 244.7ºC

 Use of phosphocyclocreatine


Cyclocreatine phosphate is an anti-tumor agent. Cyclocreatine phosphate is the proposed active form of cyclocreatine (CCr), a substrate analogue of creatine kinase. Cyclocreatine phosphate has anti-tumour activity and can be used for the research of cancer[1].

 Names

Name 2-(2-imino-3-phosphonoimidazolidin-1-yl)acetic acid
Synonym More Synonyms

 phosphocyclocreatine Biological Activity

Description Cyclocreatine phosphate is an anti-tumor agent. Cyclocreatine phosphate is the proposed active form of cyclocreatine (CCr), a substrate analogue of creatine kinase. Cyclocreatine phosphate has anti-tumour activity and can be used for the research of cancer[1].
Related Catalog
In Vivo Cyclocreatine phosphate (CCr'P) (i.p.; 37.5 mg/mL; 0.2 mL, twice daily) has anti-tumor activity without any notable signs of toxicity in a mouse xenograft model for human prostate cancer[1]. Animal Model: Athymic (CDl-Nu/Nu) male mice[1] Dosage: 37.5 mg/mL Administration: intraperitoneally , 0.2 mL, twice daily Result: Showed anti-tumor effect.
References

[1]. Rima Kaddurah-Daouk, et al. Creatine phosphate, creatine phosphate analogs, and uses therefor. Patent. WO1994016712A1.

 Chemical & Physical Properties

Density 2.03g/cm3
Boiling Point 481ºC at 760 mmHg
Molecular Formula C5H10N3O5P
Molecular Weight 223.12400
Flash Point 244.7ºC
Exact Mass 223.03600
PSA 134.97000
Index of Refraction 1.733

 Synonyms

Phosphocyclocreatine
N-Phosphorylcyclocreatine
[(2e)-2-imino-3-phosphonoimidazolidin-1-yl]acetic acid
Cyclocreatine phosphate
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