(Rac)-Lanicemine

Modify Date: 2024-01-13 16:17:56

(Rac)-Lanicemine Structure
(Rac)-Lanicemine structure
Common Name (Rac)-Lanicemine
CAS Number 61890-25-3 Molecular Weight 198.26400
Density N/A Boiling Point N/A
Molecular Formula C13H14N2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (Rac)-Lanicemine


(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].

 Names

Name 1-Phenyl-2-(2-pyridinyl)ethanamine
Synonym More Synonyms

 (Rac)-Lanicemine Biological Activity

Description (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].
Related Catalog
Target

NMDA receptor[1]

In Vivo Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1].Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3, 10 or 30 mg/kg Administration: Intraperitoneal Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.
References

[1]. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85.

 Chemical & Physical Properties

Molecular Formula C13H14N2
Molecular Weight 198.26400
Exact Mass 198.11600
PSA 38.91000
LogP 3.02440

 Safety Information

HS Code 2933399090

 Synthetic Route

~%

(Rac)-Lanicemine Structure

(Rac)-Lanicemine

CAS#:61890-25-3

Literature: Bower; Ramage Journal of the Chemical Society, 1957 , p. 4506,4509

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1-phenyl-2-pyridin-2-yl-ethylamine
2-aziridin-1-yl-1-phenyl-ethanol
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