TRIHEPTANOIN

Modify Date: 2025-08-27 16:38:14

TRIHEPTANOIN Structure
TRIHEPTANOIN structure
Common Name TRIHEPTANOIN
CAS Number 620-67-7 Molecular Weight 428.603
Density 1.0±0.1 g/cm3 Boiling Point 470.0±12.0 °C at 760 mmHg
Molecular Formula C24H44O6 Melting Point N/A
MSDS N/A Flash Point 195.5±19.6 °C

 Use of TRIHEPTANOIN


Triheptanoin (Propane-1,2,3-triyl triheptanoate) is a synthetic medium-chain triglyceride (MCT) consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin can be used for the research of inherited metabolic disorders[1].

 Names

Name triheptanoin
Synonym More Synonyms

 TRIHEPTANOIN Biological Activity

Description Triheptanoin (Propane-1,2,3-triyl triheptanoate) is a synthetic medium-chain triglyceride (MCT) consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin can be used for the research of inherited metabolic disorders[1].
Related Catalog
In Vivo In long-chain fatty acid oxidation disorders (LC-FAOD), Triheptanoin is used as an anaplerotic compound, acting as a source of calories and fatty acids to bypass the LC-FAOD enzyme deficiencies[1]. Triheptanoin can be used for the research of ataxia-telangiectasia (A-T)[2]. Triheptanoin functions as an anaplerotic agent replenishing tricarboxylic acid (TCA) cycle intermediates by metabolism to heptanoate (C7) and subsequently acetyl-CoA and propionyl-CoA that feed into the TCA cycle to supply energy[2]. Triheptanoin mitigates brain ATP depletion and mitochondrial dysfunction, including respiration and redox balance in a mouse model of Alzheimer's disease, supporting the energy failure hypothesis for that disorder[2]. Triheptanoin (Mice were treated with Triheptanoin (35E%) for 10 days prior to pilocarpine injection to induce status epilepticus) preserved mitochondrial functions in the hippocampal formations of pilocarpine-induced status epilepticus (SE) mice[3]. Animal Model: 7-8 week old male CD1 (35-40 g)[3] Dosage: 35E% oral Triheptanoin was mixed into mouse chow Administration: Given 35E% Triheptanoin treatment 10 days prior to SE induction Result: Preserved mitochondrial functions in SE mice.
References

[1]. Matt Shirley. Triheptanoin: First Approval. Drugs. 2020 Oct;80(15):1595-1600.

[2]. A J Yeo, et al. An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T). Mol Metab. 2021 Dec;54:101354.

[3]. Kah Ni Tan, et al. Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. J Neurochem. 2018 Feb;144(4):431-442.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 470.0±12.0 °C at 760 mmHg
Molecular Formula C24H44O6
Molecular Weight 428.603
Flash Point 195.5±19.6 °C
Exact Mass 428.313782
PSA 78.90000
LogP 7.73
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.457

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MB2660000
CHEMICAL NAME :
Glycerol triheptanoate
CAS REGISTRY NUMBER :
620-67-7
BEILSTEIN REFERENCE NO. :
1807724
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C24-H44-O6
MOLECULAR WEIGHT :
428.68
WISWESSER LINE NOTATION :
6VO1YOV6&1OV6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
APSCAX Acta Physiologica Scandinavica. (Karolinska Institutet, S-10401 Stockholm, Sweden) V.1- 1940- Volume(issue)/page/year: 40,338,1957

 Safety Information

Hazard Codes Xi
Risk Phrases 38
HS Code 2915900090

 Synthetic Route

~%

TRIHEPTANOIN Structure

TRIHEPTANOIN

CAS#:620-67-7

Literature: Ozaki Biochemische Zeitschrift, 1926 , vol. 177, p. 166 Proceedings of the Imperial Academy (Tokyo), vol. 2, p. 343 Chem. Zentralbl., 1926 , vol. 97, # II p. 2451

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2915900090
Summary 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

 Synonyms

Triheptanoin
Glycerol-1,2,3-triheptanoate
TRIHEPTANION
trioenanthoin
Propane-1,2,3-triyl triheptanoate
trienanthoin
propane-1,2,3-triyl trisheptanoate
1,2,3-Propanetriyl triheptanoate
glyceryl triheptanoate
glycerol trienanthate
1,2,3-tris-heptanoyloxy-propane
glyceroltriheptanoate
triheptylin
tri-heptanoi
1,2,3-Tris-heptanoyloxy-propan
Heptanoic acid, 1,2,3-propanetriyl ester
triheptanoicglyceride
TRIOENANTHIN
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