bendazol

Modify Date: 2024-01-02 13:48:09

bendazol Structure
bendazol structure
 Common Name bendazol
CAS Number 621-72-7 Molecular Weight 208.258
Density 1.2±0.1 g/cm3 Boiling Point 453.5±24.0 °C at 760 mmHg
Molecular Formula C14H12N2 Melting Point 187ºC
MSDS N/A Flash Point 252.1±9.3 °C

 Use of bendazol


Bendazol is a hypotensive drug which can also enhance NO synthase activity in renal glomeruli and collecting tubules.

 Names

Name 2-Benzyl-1H-benzimidazole
Synonym More Synonyms

 bendazol Biological Activity

Description Bendazol is a hypotensive drug which can also enhance NO synthase activity in renal glomeruli and collecting tubules.
Related Catalog
Target

NO synthase[1]

References

[1]. Eliseeva EV, et al. Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension. Bull Exp Biol Med. 2017 Jan;162(3):357-361.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 453.5±24.0 °C at 760 mmHg
Melting Point 187ºC
Molecular Formula C14H12N2
Molecular Weight 208.258
Flash Point 252.1±9.3 °C
Exact Mass 208.100052
PSA 28.68000
LogP 3.93
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.680

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD6206000
CHEMICAL NAME :
Benzimidazole, 2-benzyl-
CAS REGISTRY NUMBER :
621-72-7
BEILSTEIN REFERENCE NO. :
0159495
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C14-H12-N2
MOLECULAR WEIGHT :
208.28
WISWESSER LINE NOTATION :
T56 BM DNJ C1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: (1),44,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(6),25,1990
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
504 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 13,829,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
64400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2292473
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: (5),26,1983 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
2 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936- Volume(issue)/page/year: 43(12),10,1967

 Safety Information

Hazard Codes Xi
HS Code 2942000000

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

EINECS 210-703-6
bendazol
2-benzylbenzIMIDAZOLE
MFCD00022680
2-Benzyl-1H-benzimidazole
1H-Benzimidazole, 2-(phenylmethyl)-
bendazole
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Chemsrc provides bendazol(CAS#:621-72-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of bendazol are included as well.>> amp version: bendazol

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