1,4-Bis(chloromethyl)benzene

Modify Date: 2026-06-30 10:36:26

1,4-Bis(chloromethyl)benzene structure	Common Name	1,4-Bis(chloromethyl)benzene
	CAS Number	623-25-6	Molecular Weight	175.055
	Density	1.2±0.1 g/cm3	Boiling Point	242.5±0.0 °C at 760 mmHg
	Molecular Formula	C₈H₈Cl₂	Melting Point	98-101 °C(lit.)
	MSDS	Chinese USA	Flash Point	119.2±15.1 °C
	Symbol	GHS07, GHS09	Signal Word	Warning

Summary: 1,4-Bis(chloromethyl)benzene, also known as 1,4-dichlorobenzene, has a CAS number of 623-25-6, with a molecular formula of C8H8Cl2 and a molecular weight of 175.055. It is a white crystalline powder with a melting point of 98-101 °C and a boiling point of 242.5±0.0 °C, and a density of 1.2±0.1 g/cm3. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	alpha,alpha'-Dichloro-p-xylene
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.2±0.1 g/cm3
Boiling Point	242.5±0.0 °C at 760 mmHg
Melting Point	98-101 °C(lit.)
Molecular Formula	C₈H₈Cl₂
Molecular Weight	175.055
Flash Point	119.2±15.1 °C
Exact Mass	174.000305
LogP	2.76
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.545
Storage condition	2-8°C
Water Solubility	hydrolysis

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

1,4-Bis(chloromethyl)benzene MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZE4100000

CHEMICAL NAME :: p-Xylene, alpha,alpha'-dichloro-

CAS REGISTRY NUMBER :: 623-25-6

BEILSTEIN REFERENCE NO. :: 0774706

LAST UPDATED :: 199712

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C8-H8-Cl2

MOLECULAR WEIGHT :: 175.06

WISWESSER LINE NOTATION :: G1R D1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1280 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 501 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Liver - other changes

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 191,79,1987

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H315-H319-H410
Precautionary Statements	P273-P305 + P351 + P338-P501
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	T+:Verytoxic;
Risk Phrases	R22;R26;R36/37/38
Safety Phrases	S26-S36/37-S45-S36/37/39-S28A
RIDADR	3261
WGK Germany	3
RTECS	ZE4100000
Packaging Group	II
Hazard Class	6.1
HS Code	29036990

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:50-00-0 Formaldehyde CAS#:71-43-2 benzene CAS#:106-42-3 p-Xylene CAS#:10362-03-5 1,4-Phenylenedi...
CAS#:100-44-7 Benzyl chloride CAS#:108-88-3 Toluene CAS#:542-88-1 BIS(CHLOROMETHY... CAS#:589-29-7 1,4-Benzenedime...
CAS#:104-82-5 4-Methylbenzyl ... CAS#:128-09-6 N-chlorosuccinimide
DownStream 10
CAS#:1953-55-5 p-Xylene-.alpha... CAS#:283-80-7 [2,2,2]-paracyc... CAS#:283-81-8 [24]paracyclophane CAS#:538-39-6 1,2-di(p-tolyl)...
CAS#:2962-72-3 1,4-bis[2-(4-me... CAS#:23602-85-9 1,2-Benzenedica... CAS#:25596-72-9 Diethyl (4-chlo... CAS#:30362-89-1 Benzene,1,4-bis...
CAS#:61895-53-2 2-[[4-(chlorome... CAS#:30391-55-0 1H-Isoindole-1,...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2903999090
Summary	2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Effects of quaternization on the morphological stability and antibacterial activity of electrospun poly(DMAEMA-co-AMA) nanofibers.

Colloids Surf. B Biointerfaces 133 , 148-55, (2015)

Electrospun nanofibers with antibacterial activity are greatly promising for medical treatment and water purification. Herein we report antibacterial nanofibers electrospun from a series of poly(dimet...

Contact dermatitis caused by "chloromethyl heterocyclic intermediates".

Contact Dermatitis 16(1) , 52, (1987)

Preparation of PPV nanotubes and nanorods and carbonized products derived therefrom. Kim K and Jin J.

Nano Lett. 1(11) , 205-210, (1981)

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

MFCD00000920

G1R D1G

1,4-Bis(chloromethyl)-benzene

1,4-Bis(chloromethyl)benzene

EINECS 210-782-7

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the safety information for alpha,alpha'-Dichloro-p-xylene?

A: Safety information for alpha,alpha'-Dichloro-p-xylene: S26-S36/37-S45-S36/37/39-S28A.

Q: What are the storage conditions for alpha,alpha'-Dichloro-p-xylene?

A: Storage conditions for alpha,alpha'-Dichloro-p-xylene: 2-8°C.

Q: What English synonyms does alpha,alpha'-Dichloro-p-xylene have?

A: English synonyms of alpha,alpha'-Dichloro-p-xylene: MFCD00000920, G1R D1G, 1,4-Bis(chloromethyl)-benzene, 1,4-Bis(chloromethyl)benzene, EINECS 210-782-7.

Q: What is the molecular formula of alpha,alpha'-Dichloro-p-xylene?

A: Molecular formula of alpha,alpha'-Dichloro-p-xylene is C8H8Cl2.

Q: What are the downstream products of alpha,alpha'-Dichloro-p-xylene?

A: Related downstream products(CAS) of alpha,alpha'-Dichloro-p-xylene: 1953-55-5;283-80-7;283-81-8;538-39-6;2962-72-3;23602-85-9;25596-72-9;30362-89-1;61895-53-2;30391-55-0.

Q: How is the water solubility of alpha,alpha'-Dichloro-p-xylene?

A: Water solubility of alpha,alpha'-Dichloro-p-xylene: hydrolysis.

Q: What is the melting point of alpha,alpha'-Dichloro-p-xylene?

A: Melting point of alpha,alpha'-Dichloro-p-xylene is 98-101 °C(lit.).

Q: What is the boiling point of alpha,alpha'-Dichloro-p-xylene?

A: Boiling point of alpha,alpha'-Dichloro-p-xylene is 242.5±0.0 °C at 760 mmHg.

Q: What is the molecular weight of alpha,alpha'-Dichloro-p-xylene?

A: Molecular weight of alpha,alpha'-Dichloro-p-xylene is 175.055.

Q: What is the LogP of alpha,alpha'-Dichloro-p-xylene?

A: LogP of alpha,alpha'-Dichloro-p-xylene is 2.76.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1,4-Bis(chloromethyl)benzene
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: alpha,alpha'-Dichloro-p-xylene
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: alpha,alpha'-Dichloro-p-xylene
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 1,4-Bis(chloromethyl)benzene
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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1,4-Bis(chloromethyl)benzene

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

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1,4-Bis(chloromethyl)benzene | FAQ

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