9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE

Modify Date: 2024-01-10 18:49:54

9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE Structure
9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE structure
 Common Name 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE
CAS Number 62410-84-8 Molecular Weight 336.47
Density 1.1±0.1 g/cm3 Boiling Point 516.2±50.0 °C at 760 mmHg
Molecular Formula C20H32O4 Melting Point N/A
MSDS N/A Flash Point 177.6±23.6 °C

 Use of 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE


Prostaglandin F2α 1,11-lactone is a prostaglandin.Prostaglandin F2α 1,11-lactone is absorbed by the eye. Prostaglandin F2α 1,11-Lactone has metabolic stability on the corneal surface and conjunctiva.Prostaglandin F2α 1,11-lactone can be used in the treatment of glaucoma[1].

 Names

Name (2E,5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hepta-2,5-dienal
Synonym More Synonyms

  Biological Activity

Description Prostaglandin F2α 1,11-lactone is a prostaglandin.Prostaglandin F2α 1,11-lactone is absorbed by the eye. Prostaglandin F2α 1,11-Lactone has metabolic stability on the corneal surface and conjunctiva.Prostaglandin F2α 1,11-lactone can be used in the treatment of glaucoma[1].
Related Catalog
References

[1]. Chien DS, et al. Ocular penetration and bioconversion of prostaglandin F2alpha prodrugs in rabbit cornea and conjunctiva. J Pharm Sci. 1997 Oct;86(10):1180-6.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 516.2±50.0 °C at 760 mmHg
Molecular Formula C20H32O4
Molecular Weight 336.47
Flash Point 177.6±23.6 °C
Exact Mass 336.230072
PSA 66.76000
LogP 2.80
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.545

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UK8020500
CHEMICAL NAME :
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, iota-lactone, (5Z,9-alpha,11-alpha, 13E,15S)-
CAS REGISTRY NUMBER :
62410-84-8
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H32-O4
MOLECULAR WEIGHT :
336.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
400 ug/kg
SEX/DURATION :
female 4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1089,1983

 Synonyms

(9α,11α,13E,15S)-9,15-Dihydroxy-1,11-epoxyprosta-5,13-dien-1-one
Prosta-5,13-dien-1-one, 1,11-epoxy-9,15-dihydroxy-, (9α,11α,13E,15S)-
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Chemsrc provides CAS#:62410-84-8 MSDS, density, melting point, boiling point, structure, etc. Its name is 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE>> amp version: 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE

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