Prostaglandin D2
Modify Date: 2026-07-16 17:22:35
Prostaglandin D2 structure
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Common Name | Prostaglandin D2 | ||
|---|---|---|---|---|
| CAS Number | 41598-07-6 | Molecular Weight | 352.465 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 549.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H32O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 300.3±26.6 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
Use of Prostaglandin D2Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3]. |
| Name | prostaglandin D2 |
|---|---|
| Synonym | More Synonyms |
| Description | Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vivo | Prostaglandin D2 (PGD2; infused into the lateral ventricle; 5-50 pmol/min; for 6 hours between 20:00 and 2:00) induces sleep-wake profiles in A2AR KO mice[2]. Animal Model: Male WT and A2AR KO mice of the inbred C57BL/6 strain (weighing 23-27 g, 11-13 weeks old)[1] Dosage: 5, 10, 20, or 50 pmol/min Administration: Infused into the lateral ventricle; for 6 hours between 20:00 and 2:00 Result: Induced sleep-wake profiles. |
| References |
[1]. Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385(2):321-8. |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 549.6±50.0 °C at 760 mmHg |
| Molecular Formula | C20H32O5 |
| Molecular Weight | 352.465 |
| Flash Point | 300.3±26.6 °C |
| Exact Mass | 352.224976 |
| PSA | 94.83000 |
| LogP | 2.02 |
| Vapour Pressure | 0.0±3.4 mmHg at 25°C |
| Index of Refraction | 1.561 |
| InChIKey | BHMBVRSPMRCCGG-OUTUXVNYSA-N |
| SMILES | CCCCCC(O)C=CC1C(=O)CC(O)C1CC=CCCCC(=O)O |
| Storage condition | 20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H360 |
| Precautionary Statements | P201-P308 + P313 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T: Toxic; |
| Risk Phrases | 60-22 |
| Safety Phrases | S22;S26;S36;S53 |
| RIDADR | NONH for all modes of transport |
| RTECS | UK7930000 |
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HMDB: a knowledgebase for the human metabolome.
Nucleic Acids Res. 37(Database issue) , D603-10, (2009) The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ... |
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The human serum metabolome.
PLoS ONE 6(2) , e16957, (2011) Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m... |
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Malva sylvestris L. extract suppresses desferrioxamine-induced PGE₂ and PGD₂ release in differentiated U937 cells: the development and validation of an LC-MS/MS method for prostaglandin quantification.
Biomed. Chromatogr. 28(7) , 986-93, (2014) Malva sylvestris is a species used worldwide as an alternative to anti-inflammatory therapies; however, its mechanism of action remains unknown. In this paper, the anti-inflammatory effects of M. sylv... |
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Name: Human DP2 receptor (Prostanoid receptors)
Source: IUPHAR-DB
Target: DP2 receptor (Prostanoid receptors) [Homo sapiens]
External Id: 339_Human
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Name: Mouse DP1 receptor (Prostanoid receptors)
Source: IUPHAR-DB
Target: DP1 receptor (Prostanoid receptors) [Mus musculus]
External Id: 338_Mouse
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Name: Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: ORF 73 [Human herpesvirus 8 type M]
External Id: HMS791
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Name: Rat DP1 receptor (Prostanoid receptors)
Source: IUPHAR-DB
Target: DP1 receptor (Prostanoid receptors) [Rattus norvegicus]
External Id: 338_Rat
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Name: Human FP receptor (Prostanoid receptors)
Source: IUPHAR-DB
Target: FP receptor (Prostanoid receptors) [Homo sapiens]
External Id: 344_Human
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Name: TP_TRANSPORTER: inhibition of PGE2 uptake (PGE2: 0.015 uM) by Prostaglandin D2 at 0.1...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 3A1
External Id: CHEMBL2075872
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Name: Human EP2 receptor (Prostanoid receptors)
Source: IUPHAR-DB
Target: EP2 receptor (Prostanoid receptors) [Homo sapiens]
External Id: 341_Human
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Name: A screen for small molecules that modulate mitochondrial supercomplex formation
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1482
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Name: Rat EP2 receptor (Prostanoid receptors)
Source: IUPHAR-DB
Target: EP2 receptor (Prostanoid receptors) [Rattus norvegicus]
External Id: 341_Rat
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Name: Human DP1 receptor (Prostanoid receptors)
Source: IUPHAR-DB
Target: DP1 receptor (Prostanoid receptors) [Homo sapiens]
External Id: 338_Human
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| PGD2 |
| (5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid |
| Prostaglandin D2 |
| (5Z,9α,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oic acid |
| MFCD00077857 |