Dihydro-5-azacytidine

Modify Date: 2024-01-16 11:55:57

Dihydro-5-azacytidine structure	Common Name	Dihydro-5-azacytidine
	CAS Number	62488-57-7	Molecular Weight	246.221
	Density	2.1±0.1 g/cm3	Boiling Point	529.1ºC at 760 mmHg
	Molecular Formula	C₈H₁₄N₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	273.8ºC

Use of Dihydro-5-azacytidine

Dihydro-5-azacytidine (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine has an antitumor activity[1][2].

Name	5,6-Dihydro-5-azacytidine
Synonym	More Synonyms

Description	Dihydro-5-azacytidine (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine has an antitumor activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Signaling Pathways >> Epigenetics >> DNA Methyltransferase
In Vitro	Methylation studies show that an LD10 dose of [3H]DHAC results in a 25.06% hypomethylation of DNA in L1210/0 cells and a 46.32% hypomethylation in a deoxycytidine kinase mutant cell line L1210/dCK(-), compared with their respective controls[2]. Dihydro-5-azacytidine (DHAC) competes with cytidine triphosphate for incorporation into RNA, leading to ribosomal degradation and defective protein synthesis[1].
In Vivo	In tumor-bearing mice (injected with L1210/0 cells), after an LD10 dose of Dihydro-5-azacytidine (DHAC; 1500 mg/kg), the plasma peak concentration achieved is 317 μM and is eliminated biexponentially, with a t1/2 α of 1.03 h and a t1/2 β of 5 h[2].
References	[1]. Robert A Kratzke, et al. Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904. J Thorac Oncol. 2008 Apr;3(4):417-21. [2]. W C Powell, et al. Biochemical pharmacology of 5,6-dihydro-5-azacytidine (DHAC) and DNA hypomethylation in tumor (L1210)-bearing mice. Cancer Chemother Pharmacol. 1988;21(2):117-21.

Density	2.1±0.1 g/cm3
Boiling Point	529.1ºC at 760 mmHg
Molecular Formula	C₈H₁₄N₄O₅
Molecular Weight	246.221
Flash Point	273.8ºC
Exact Mass	246.096420
PSA	140.64000
LogP	-2.20
Index of Refraction	1.823

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ3018500

CHEMICAL NAME :: s-Triazin-2(1H)-one, 5,6-dihydro-4-amino-1-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 62488-57-7

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C8-H14-N4-O5

MOLECULAR WEIGHT :: 246.26

WISWESSER LINE NOTATION :: T6NVN EN DHJ EZ C- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Embryo

DOSE/DURATION :: 30 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,817,1982

1,3,5-triazin-2(1H)-one, 4-amino-5,6-dihydro-1-β-D-ribofuranosyl-

4-Amino-1-(β-D-ribofuranosyl)-5,6-dihydro-1,3,5-triazin-2(1H)-one

5,6 dihydro-5-azacytidine

1,3,5-Triazin-2(1H)-one, 4-amino-3,6-dihydro-1-β-D-ribofuranosyl-

6-Amino-3-(β-D-ribofuranosyl)-3,4-dihydro-1,3,5-triazin-2(1H)-one

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: "5,6-Dihydro-5-azacytidine"
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: 5,6-Dihydro-5-azacytidine
Price: $1100.0/100mg $1800.0/250mg $3500.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: 5,6-Dihydro-5-azacytidine
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,3,5-Triazin-2(1H)-one,4-amino-3,6-dihydro-1-b-D-ribofuranosyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

Dihydro-5-azacytidine suppliers

Dihydro-5-azacytidine price

Dihydro-5-azacytidine

Use of Dihydro-5-azacytidine

Names