Progabide
Progabide structure
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Common Name | Progabide | ||
|---|---|---|---|---|
| CAS Number | 62666-20-0 | Molecular Weight | 334.77300 | |
| Density | 1.3g/cm3 | Boiling Point | 525.363ºC at 760 mmHg | |
| Molecular Formula | C17H16ClFN2O2 | Melting Point | 133-135°; mp 142.5° (Kaplan, J. Med. Chem.) | |
| MSDS | N/A | Flash Point | 271.53ºC | |
Use of ProgabideProgabide is a gamma-aminobutyric acid receptor (GABA) agonist. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. |
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| Related Catalog | |
| Target |
GABA receptor[1] |
| In Vivo | Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. Doses of 50, 100 and 200 mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244, 365 and 476% respectively (t=6.44 to12.55, p<0.01). 10 mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide[1]. |
| Animal Admin | Male Wistar rats weighing 170 to 240 g are caged in groups of three under diurnal lighting conditions with free access to food and water. The rats are accustomed to handling (housing 1 per cage for 30 min, injecting with saline, 1 mL/100 g body weight) in the period of 7 days before the beginning of the experiment. Progabide is injected as a suspension in saline containing 0.1% Tween 80. Control rats are treated IP with the corresponding vehicle (1 mL/100 g body weight). Ether stress is performed and 15 min after the beginning of the stressful procedure the animals are sacrificed[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3g/cm3 |
|---|---|
| Boiling Point | 525.363ºC at 760 mmHg |
| Melting Point | 133-135°; mp 142.5° (Kaplan, J. Med. Chem.) |
| Molecular Formula | C17H16ClFN2O2 |
| Molecular Weight | 334.77300 |
| Flash Point | 271.53ºC |
| Exact Mass | 334.08800 |
| PSA | 75.68000 |
| LogP | 3.98790 |
| Index of Refraction | 1.59 |
| InChIKey | IBALRBWGSVJPAP-UHFFFAOYSA-N |
| SMILES | NC(=O)CCCN=C(c1ccc(Cl)cc1)c1cc(F)ccc1O |
| Storage condition | 2-8℃ |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| HS Code | 2925290090 |
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Progabide CAS#:62666-20-0 |
| Literature: DE2634288 , ; Chem.Abstr., , vol. 86, # 189530 |
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Progabide CAS#:62666-20-0 |
| Literature: DE2634288 , ; Chem.Abstr., , vol. 86, # 189530 |
![4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanoic acid structure](https://image.chemsrc.com/caspic/325/62665-97-8.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
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| DownStream 0 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2925290090 |
|---|---|
| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Progabide |
| Gabren (TN) |
| Progabide (USAN/INN) |
| 4-[[(4-chlorophenyl)-(5-fluoro-2-hydroxyphenyl)methylene]amino]butanamide |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide? |
| A: SMILES notation of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide is NC(=O)CCCN=C(c1ccc(Cl)cc1)c1cc(F)ccc1O. |
| Q: What is the English name of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide? |
| A: The English name of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide is 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide. |
| Q: What is the melting point of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide? |
| A: Melting point of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide is 133-135°; mp 142.5° (Kaplan, J. Med. Chem.). |
| Q: What are the uses of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide? |
| A: Main uses of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide: Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. |
| Q: What is the molecular formula of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide? |
| A: Molecular formula of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide is C17H16ClFN2O2. |
| Q: What is the polar surface area (PSA) of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide? |
| A: Polar surface area (PSA) of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide is 75.68000. |
| Q: What is the boiling point of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide? |
| A: Boiling point of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide is 525.363ºC at 760 mmHg. |
| Q: What are the storage conditions for 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide? |
| A: Storage conditions for 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide: 2-8℃. |
| Q: What are the upstream materials of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide? |
| A: Related upstream materials(CAS) of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide: 62665-97-8;62433-26-5. |
| Q: What English synonyms does 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide have? |
| A: English synonyms of 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide: Progabide, Gabren (TN), Progabide (USAN/INN), 4-[[(4-chlorophenyl)-(5-fluoro-2-hydroxyphenyl)methylene]amino]butanamide. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |