DC Chemicals Limited
China
Product Name: Progabide
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Purity: 98.0%
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Contact: Tony Cao

62666-20-0

62666-20-0 structure

62666-20-0 structure

Name: Progabide
Chemical Name: 4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide
CAS Number: 62666-20-0
Molecular Formula: C₁₇H₁₆ClFN₂O₂
Molecular Weight: 334.77300
Catalog: API Nervous system medication Antiepileptic and anticonvulsant
Create Date: 2018-09-29 12:14:32
Modify Date: 2024-01-02 10:21:20
Progabide is a gamma-aminobutyric acid receptor (GABA) agonist.

Name	4-[[(Z)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide
Synonyms	Progabide Gabren (TN) Progabide (USAN/INN) 4-[[(4-chlorophenyl)-(5-fluoro-2-hydroxyphenyl)methylene]amino]butanamide

Description	Progabide is a gamma-aminobutyric acid receptor (GABA) agonist.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	GABA receptor[1]
In Vivo	Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. Doses of 50, 100 and 200 mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244, 365 and 476% respectively (t=6.44 to12.55, p<0.01). 10 mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide[1].
Animal Admin	Male Wistar rats weighing 170 to 240 g are caged in groups of three under diurnal lighting conditions with free access to food and water. The rats are accustomed to handling (housing 1 per cage for 30 min, injecting with saline, 1 mL/100 g body weight) in the period of 7 days before the beginning of the experiment. Progabide is injected as a suspension in saline containing 0.1% Tween 80. Control rats are treated IP with the corresponding vehicle (1 mL/100 g body weight). Ether stress is performed and 15 min after the beginning of the stressful procedure the animals are sacrificed[1].
References	[1]. Manev H, et al. Progabide, a GABA mimetic drug, stimulates the secretion of plasma corticosterone in rats. Pharmacol Biochem Behav. 1987 Dec;28(4):443-6.

Density	1.3g/cm3
Boiling Point	525.363ºC at 760 mmHg
Melting Point	133-135°; mp 142.5° (Kaplan, J. Med. Chem.)
Molecular Formula	C₁₇H₁₆ClFN₂O₂
Molecular Weight	334.77300
Flash Point	271.53ºC
Exact Mass	334.08800
PSA	75.68000
LogP	3.98790
Index of Refraction	1.59
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ3500970

CHEMICAL NAME :: Butanamide, 4-(((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyle ne)amino)-

CAS REGISTRY NUMBER :: 62666-20-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H16-Cl-F-N2-O2

MOLECULAR WEIGHT :: 334.80

WISWESSER LINE NOTATION :: ZV3NUYR DG&R BQ EF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: LMSED6 L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches Synthelabo Monograph Series. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1983- Volume(issue)/page/year: 3,203,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: LMSED6 L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches Synthelabo Monograph Series. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1983- Volume(issue)/page/year: 3,203,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4094992 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 655 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Endocrine - adrenal cortex tumors

REFERENCE :: LMSED6 L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches Synthelabo Monograph Series. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1983- Volume(issue)/page/year: 3,203,1985

HS Code	2925290090

62665-97-8 structure

62665-97-8

~%

62666-20-0 structure

62666-20-0

Literature: DE2634288 , ; Chem.Abstr., , vol. 86, # 189530

62433-26-5 structure

62433-26-5

~%

62666-20-0 structure

62666-20-0

Literature: DE2634288 , ; Chem.Abstr., , vol. 86, # 189530

Precursor 2
62665-97-8 62433-26-5
DownStream 0

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%