NSC45586

Modify Date: 2025-08-25 15:19:14

NSC45586 Structure
NSC45586 structure
Common Name NSC45586
CAS Number 6300-44-3 Molecular Weight 412.38
Density 1.43g/cm3 Boiling Point 675.7ºC at 760mmHg
Molecular Formula C20H17N6NaO3 Melting Point N/A
MSDS N/A Flash Point 362.5ºC

 Use of NSC45586


NSC45586 sodium is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 sodium targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons[1].

 Names

Name sodium,(3Z)-3-[[4-[(2,4-diamino-5-methylphenyl)diazenyl]phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylic acid

 NSC45586 Biological Activity

Description NSC45586 sodium is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 sodium targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons[1].
Related Catalog
References

[1]. Jackson TC, et, al. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28.

 Chemical & Physical Properties

Density 1.43g/cm3
Boiling Point 675.7ºC at 760mmHg
Molecular Formula C20H17N6NaO3
Molecular Weight 412.38
Flash Point 362.5ºC
Exact Mass 413.13400
PSA 159.01000
LogP 6.55640
Index of Refraction 1.702
Storage condition -20°C
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